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A multifunctional sensor for cell traction force, matrix remodeling and biomechanical assays in self-assembled 3D tissues in vitro.
Nat Protoc
January 2025
Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Cell-matrix interactions, mediated by cellular force and matrix remodeling, result in dynamic reciprocity that drives numerous biological processes and disease progression. Currently, there is no available method for directly quantifying cell traction force and matrix remodeling in three-dimensional matrices as a function of time. To address this long-standing need, we developed a high-resolution microfabricated device that enables longitudinal measurement of cell force, matrix stiffness and the application of mechanical stimulation (tension or compression) to cells.
View Article and Find Full Text PDFDynamic nanomechanical characterization of cells in exosome therapy.
Microsyst Nanoeng
July 2024
CAS Key Laboratory of Mechanical Behavior and Design of Material, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui 230027 China.
Article Synopsis
- Exosomes from mesenchymal stem cells (MSCs) boost cell growth and tissue healing by releasing their contents into recipient cells, playing a key role in early-stage treatment effects, though more research is needed on their early therapeutic benefits.
- The study introduces a method to measure the ability of exosomes to improve the cytoskeleton and cell contractility through three-dimensional cell traction force, visualizing exosome effects in real time without damaging cells.
- Findings indicate that endometrial stromal cells show increased traction force and altered cell shape in response to exosome therapy, linked to the regulation of the Rac1/RhoA signaling pathway, ultimately enhancing cell proliferation.
Mutual antagonism between CD44 and integrins in glioblastoma cell traction and migration.
APL Bioeng
September 2024
Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Cell migration is the major driver of invasion and metastasis during cancer progression. For cells to migrate, they utilize the actin-myosin cytoskeleton and adhesion molecules, such as integrins and CD44, to generate traction forces in their environment. CD44 primarily binds to hyaluronic acid (HA) and integrins primarily bind to extracellular matrix (ECM) proteins such as collagen.
View Article and Find Full Text PDFGlioblastoma Cells Use an Integrin- and CD44-Mediated Motor-Clutch Mode of Migration in Brain Tissue.
Cell Mol Bioeng
April 2024
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA.
Purpose: Glioblastoma (GBM) is an aggressive malignant brain tumor with 2 year survival rates of 6.7% (Stupp et al. in J Clin Oncol Off J Am Soc Clin Oncol 25:4127-4136, 2007; Mohammed et al.
View Article and Find Full Text PDFSpatial confinement modulates endothelial cell behavior and traction force in 3D hydrogel microgrooves.
Mater Today Bio
June 2024
Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, PR China.
The mechanical environment of vascular endothelial cells (ECs) encompasses a wide range of curvatures due to variations in blood vessel diameters. Integrins, key mediators of cell-matrix interactions, establish connections between the extracellular matrix and the actin cytoskeleton, influencing diverse cellular behaviors. In this study, we explored the impact of spatial confinement on human umbilical vein ECs (HUVECs) cultured within three-dimensional hydrogel microgrooves of varying curvatures and the underlying role of integrins in mediating cellular responses.
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