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Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties. | LitMetric
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Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties.

Larisa K Shubina Tatyana N Makarieva Sergey A Dyshlovoy Sergey N Fedorov Pavel S Dmitrenok Valentin A Stonik

Nat Prod Commun

Laboratory of Chemistry MaNaPro, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok, Russia.

Published: December 2010

Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.

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