AI Article Synopsis
- Penicillium chrysogenum produces a protein called PAF, which inhibits the growth of various fungi, especially Aspergillus nidulans, but has little effect on itself.
- This study reveals that PAF does more than just fight off other fungi; it also promotes conidiation (spore formation) in P. chrysogenum by influencing the expression of a key regulatory gene, brlA.
- A strain of P. chrysogenum lacking PAF showed significantly reduced spore formation, suggesting that PAF is crucial for normal asexual reproduction in this fungus.
Article Abstract
Penicillium chrysogenum secretes a low molecular weight, cationic and cysteine-rich protein (PAF). It has growth inhibitory activity against the model organism Aspergillus nidulans and numerous zoo- and phytopathogenic fungi but shows only minimal conditional antifungal activity against the producing organism itself. In this study we provide evidence for an additional function of PAF which is distinct from the antifungal activity against putative ecologically concurrent microorganisms. Our data indicate that PAF enhances conidiation in P. chrysogenum by modulating the expression of brlA, the central regulatory gene for mitospore development. A paf deletion strain showed a significant impairment of mitospore formation which sustains our hypothesis that PAF plays an important role in balancing asexual differentiation in P. chrysogenum.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103751 | PMC |
| http://dx.doi.org/10.1002/jobm.201000321 | DOI Listing |
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