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Cellular RNA interacts with MAVS to promote antiviral signaling.
Science
December 2024
Department of Immunology, University of Washington, Seattle, WA.
Antiviral signaling downstream of RIG-I-like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA molecules that provide allosteric regulation or act as molecular guides or scaffolds. We hypothesized that RNA plays a role in organizing MAVS signaling platforms.
View Article and Find Full Text PDFA survey of quit vaping strategies and relapse triggers for maintaining youth and young adult vaping abstinence in Canada.
J Addict Dis
December 2024
Department of Psychology, Saint Mary's University, Halifax, Canada.
Objectives: To examine whether various quit strategies and relapse triggers are associated with maintenance period in a sample of people who quit vaping.
Method: Young Canadians who used to vape ( = 772) completed an online survey on maintenance period, quit strategies, and relapse triggers. Logistic regression was employed to variables associated with maintenance period.
Key element missed in nutrition policy: why does undernutrition not decline among pregnant women in Ethiopia?
Health Res Policy Syst
December 2024
Department of Public Health, Institute of Health and Medical Science, Bule Hora University, Bule Hora, Ethiopia.
Pregnancy is the most delicate stage in human life that requires high quality and several types of food to meet maternal and foetal nutritional demands. During pregnancy, food taboo is practised habitually by Ethiopian women, suggesting that they are affected by macro and micronutrient deficiencies. In Ethiopia, there is a greater magnitude of food taboo practices during pregnancy.
View Article and Find Full Text PDFImmunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate.
PLoS Pathog
December 2024
Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million people are infected by this parasite of which 20-30% will progress to develop Chronic Chagasic Cardiomyopathy (CCC). Despite its high disease burden, no clinically approved vaccine exists for the prevention or treatment of CCC.
View Article and Find Full Text PDFEnergy restriction inhibits β-catenin ubiquitination to improve ischemic stroke injury via USP18/SKP2 axis.
Metab Brain Dis
December 2024
Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, P.R. China.
Ischemic stroke (IS) remains a global health issue because of its great disability and mortality. Energy restriction (ER) has been justified to perform an inhibitory role in cerebral injury caused by IS. This research was purposed to inquire the potential molecular mechanism of ER in IS.
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