AI Article Synopsis
- hCG is essential for a healthy pregnancy, influencing processes like blood vessel formation and immune system regulation.
- Despite extensive research, the causes of preeclampsia—characterized by inadequate trophoblast invasion and poor blood vessel remodeling—are still unclear and linked to immune system issues.
- The paper explores how hCG interacts with trophoblasts and endothelial cells and suggests that changes in the function and sugar structure of hCG might be involved in the development of preeclampsia.
Article Abstract
Human chorionic gonadotropin (hCG) is crucial for successful pregnancy. Its many functions include angiogenesis and immune regulation. Despite years of research, the etiology of preeclampsia remains unknown. Marked by insufficient trophoblast invasion and poor spiral artery remodeling, preeclampsia has also been linked to immune dysregulation. Here we discuss the roles of hCG in the context of endovascular cross-talk between trophoblasts and endothelial cells and immune tolerance. We propose that functional and glycosylation modifications of hCG may contribute to the pathogenesis of preeclampsia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061407 | PMC |
| http://dx.doi.org/10.1016/j.placenta.2011.01.009 | DOI Listing |
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