AI Article Synopsis
- A new thrombin inhibitor was created by combining two existing compounds: an aminopyridinoneacetamide and a 1,3,5-trisubstituted phenyl ether.
- The design led to the development of potent biaryl 1,3,5-trisubstituted benzenes.
- This new series showed strong effectiveness as anticoagulants.
Article Abstract
A novel 1,3,5-trisubstituted benzamide thrombin inhibitor template was designed via hybridization of a known aminopyridinoneacetamide and a known 1,3,5-trisubstituted phenyl ether. Optimization of this lead afforded a novel potent series of biaryl 1,3,5-trisubstituted benzenes with excellent functional anticoagulant potency.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2010.12.105 | DOI Listing |
Publication Analysis
Top Keywords
135-trisubstituted benzenes
8
design synthesis
4
synthesis sar
4
sar series
4
135-trisubstituted
4
series 135-trisubstituted
4
benzenes thrombin
4
thrombin inhibitors
4
inhibitors novel
4
novel 135-trisubstituted
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!