Objective: The paper presents a case of plasmacytoma unexpectedly found in a goiter. PATIENT MATERIAL AND METHODS: The patient presented with compressive symptoms, including dyspnea and dysphagia and had no documented prior history of multiple myeloma. Physical examination revealed thyromegaly with no specific nodule. Computerized tomographic (CT) scan of the neck and chest showed diffuse homogenous enlargement of both the thyroid lobes extending into the mediastinum. Total thyroidectomy was done because of the compressive symptoms.
Results: Pathology revealed evidence of fibrosis surrounding small nodules of residual follicles with massive infiltration by plasma cells. The pathologic diagnosis was plasmacytoma.
Conclusion: Plasmacytoma should be added to the list of causes of diffuse thyromegaly.
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Cureus
April 2024
Department of Head and Neck Surgery, Orlando Health Cancer Institute, Orlando, USA.
Extramedullary plasmacytomas without evidence of systemic illness make up less than 5% of all plasma cell neoplasms. The incidence of extramedullary plasmacytoma of the thyroid region is exceedingly rare. This report discusses the case of a 72-year-old male with extramedullary plasmacytoma of the thyroid.
View Article and Find Full Text PDFBiomol Biomed
September 2024
Department of Endocrinology 2, Central Hospital Affiliated to Shenyang Medical College, Tiexi District, Shenyang, Liaoning Province, China.
Hashimoto's thyroiditis (HT) is a prevalent autoimmune disease. We investigated the relationship of peripheral blood long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) and microRNA (miR)-146a levels with Th17/Treg-related cytokines in HT patients and their clinical significance. Correlations of PVT1 and miR-146a with Th17/Treg-related cytokines were analyzed, and its clinical value in diagnosing HT was assessed.
View Article and Find Full Text PDFIntern Med
November 2024
Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Japan.
A 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy.
View Article and Find Full Text PDFOncol Lett
March 2024
Department of Otorhinolaryngology and Thyroid Surgery, Sapporo City General Hospital, Sapporo, Hokkaido 060-8604, Japan.
Medicine (Baltimore)
June 2023
Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
Rationale: Plasmacytoma is a disease caused by the proliferation of monoclonal immunoglobulin-producing plasma cells and divided into multiple myeloma, solitary bone plasmacytoma, and extramedullary plasmacytoma. We report a case of orbital extramedullary plasmacytoma invading the dura mater in a patient with exophthalmos and diplopia.
Patient Concerns: A 35-year-old female patient with exophthalmos in the right eye and diplopia visited the clinic.
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