AI Article Synopsis
- The study presents a highly sensitive sensor called the single nanowire-on-film (SNOF) surface-enhanced resonance Raman scattering (SERRS) sensor for detecting mercury ions (Hg(2+)) using structure-switching double stranded DNAs (dsDNAs).
- The sensor operates by changing the shape of dsDNAs upon binding with Hg(2+), allowing a Raman reporter to come closer to the SNOF structure and produce a detectable signal.
- With a detection limit of 100 pM and the ability to be reused, the SNOF sensor's design allows for potential expansion into multiplex sensors that can detect multiple targets using different modified nanowires.
Article Abstract
We report an ultrasensitive and selective single nanowire-on-film (SNOF) surface-enhanced resonance Raman scattering (SERRS) sensor for Hg(2+) detection based on structure-switching double stranded DNAs (dsDNAs). Binding of Hg(2+) induces conformational changes of the dsDNAs and let a Raman reporter get close to the SNOF structure, thereby turning on SERRS signal. The well-defined SNOF structure provides a detection limit of 100 pM with improved accuracy in Hg(2+) detection. This sensor is stable over a considerable amount of time and reusable after simple treatment. Since this SNOF sensor is composed of a single Au NW on a film, development of a multiplex sensor would be possible by employing NWs modified by multiple kinds of aptamers.
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| http://dx.doi.org/10.1002/chem.201001663 | DOI Listing |
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