Family practice is an expanding field which is beginning to produce its own literature. In order to make the job of writing an article easier, the author needs a method of organizing material and a checklist of things to remember when submitting the article for publication. This series of articles will cover the process of writing from rough notes to finished product, and will conclude with a description of the review process-what happens to an article after submission.
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The Confluence Between Spiritual and Mental Health: A Phenomenological Approach to the Study of Healthcare Professionals' Experiences.
Healthcare (Basel)
December 2024
Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain.
: Given the global concern about mental health in the world, different approaches are being explored in its approach and treatment. In this line, the care of the spiritual dimension has been shown in many studies to have a significantly positive relationship. In mental health units, the comprehensive approach that involves comprehensive care considers the spiritual dimension as an aspect of care that contributes to coping with mental health problems.
View Article and Find Full Text PDFAged Garlic Extract (AGE) and Its Constituent S-Allyl-Cysteine (SAC) Inhibit the Expression of Pro-Inflammatory Genes Induced in Bronchial Epithelial IB3-1 Cells by Exposure to the SARS-CoV-2 Spike Protein and the BNT162b2 Vaccine.
Molecules
December 2024
Department of Life Sciences and Biotechnology, Ferrara University, 44121 Ferrara, Italy.
Garlic ( L.) is a species of the onion family () widely used as a food and a folk medicine. The objective of this study was to determine the effects of AGE (aged garlic extract) on pro-inflammatory genes relevant to COVID-19.
View Article and Find Full Text PDFFunctional evidence that S-nitroso-L-cysteine may be a candidate carotid body neurotransmitter.
Neuropharmacology
March 2025
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA; Functional Electrical Stimulation Center, Case Western Reserve University, Cleveland, OH, USA.
The primary objective of the present study is to provide further evidence that the endogenous S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), plays an essential role in signaling the hypoxic ventilatory response (HVR) in rodents. Key findings were that (1) injection of L-CSNO (50 nmol/kg, IV) caused a pronounced increase in frequency of breathing (Freq), tidal volume (TV) and minute ventilation (MV) in naïve C57BL/6 mice, whereas injection of D-CSNO (50 nmol/kg, IV) elicited minimal responses; (2) L-CSNO elicited minor responses in (a) C57BL/6 mice with bilateral carotid sinus nerve transection (CSNX), (b) C57BL/6 mice treated neonatally with capsaicin (CAP) to eliminate small-diameter C-fibers, and (c) C57BL/6 mice receiving continuous infusion of L-CSNO receptor antagonists, S-methyl-L-cysteine and S-ethyl-L-cysteine (L-SMC + L-SEC, both at 5 μmol/kg/min, IV); and (3) injection of S-nitroso-L-glutathione (L-GSNO, 50 nmol/kg, IV) elicited pronounced ventilatory responses that were not inhibited by L-SMC + L-SEC. Subsequent exposure of naïve C57BL/6 mice to a hypoxic gas challenge (HXC; 10% O, 90% N) elicited pronounced increases in Freq, TV and MV that were subject to roll-off.
View Article and Find Full Text PDFInteractions of and Isolated from Light-Flavor Jiupei at Various Fermentation Temperatures.
Foods
September 2024
School of Xinghuacun, Shanxi University, Taiyuan 030006, China.
Article Synopsis
- Chinese Baijiu is a well-known alcoholic drink from China, and this study focuses on the interactions between key microorganisms during its fermentation at different temperatures.
- Results showed that one microorganism significantly reduced the growth and lactic acid production of another when the temperature was above 15 °C, while the first microorganism did not affect the growth of a third microorganism involved in ethanol production.
- A detailed analysis revealed that key enzymes for sugar metabolism and lactic acid production were less active in the presence of the dominant microorganism, highlighting its inhibitory role and offering insights for optimizing Baijiu fermentation processes.
Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants.
Neuropsychopharmacology
December 2024
Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Article Synopsis
- MDMA, known for boosting mood and empathy, was compared with its enantiomers S-MDMA and R-MDMA in a controlled study to explore their effects on participants' experiences of stimulation and psychedelia.
- S-MDMA (125 mg) produced stronger subjective effects and increased blood pressure compared to both R-MDMA doses and regular MDMA, while R-MDMA did not show notable psychedelic effects as expected.
- Pharmacokinetic analysis revealed that S-MDMA has a shorter elimination half-life (4.1 hours) and results in higher plasma levels of prolactin, cortisol, and oxytocin compared to R-MDMA, which has a longer half-life (12-14 hours) and weaker stimulant
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