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Nonlinear excitation of energetic particle driven geodesic acoustic mode by resonance overlap with Alfvén instability in ASDEX Upgrade.
Sci Rep
January 2025
National Institutes for Quantum Science and Technology, Kamikita, 039-3212, Japan.
The Alfvén instability nonlinearly excited the energetic-particle-driven geodesic acoustic mode on the ASDEX-Upgrade tokamak, as demonstrated experimentally. The mechanism of the energetic-particle-driven geodesic acoustic mode excitation and the mode nonlinear evolution is not yet fully understood. In the present work, a first-principles simulation using the MEGA code investigated the mode properties in both the linear growth and nonlinear saturated phases.
View Article and Find Full Text PDFThe expected polygenic risk score (ePRS) framework: an equitable metric for quantifying polygenetic risk via modeling of ancestral makeup.
medRxiv
December 2024
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Polygenic risk scores (PRSs) depend on genetic ancestry due to differences in allele frequencies between ancestral populations. This leads to implementation challenges in diverse populations. We propose a framework to calibrate PRS based on ancestral makeup.
View Article and Find Full Text PDFThree Underused Statistical Methods in Social Epidemiology: Multiple Informant Models, Fractional Regression, and Restricted Mean Survival Time.
Am J Epidemiol
January 2025
Center for Anti-racism, Social Justice & Public Health, New York University School of Global Public Health, New York, NY 10003, USA.
We recommend three well-established yet underused statistical methods in social epidemiology: Multiple Informant Models (MIMs), Fractional Regression Model (FRM), and Restricted Mean Survival Time (RMST). MIMs improve how we identify critical windows of exposure over time. FRM addresses the inadequacies of ordinary least squares and logistic regression when dealing with fractional outcomes that are naturally proportions or rates, thereby accommodating data at the boundaries of the unit interval without requiring transformations.
View Article and Find Full Text PDFCost-effectiveness analysis of deep brain stimulation versus treatment as usual for treatment-resistant obsessive-compulsive disorder.
J Neurosurg
January 2025
1Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Objective: Deep brain stimulation (DBS) is an effective neurosurgical option for patients with treatment-resistant obsessive-compulsive disorder (OCD). Despite being more costly than neuroablative procedures of comparable efficacy, DBS has gained popularity over the years for its reversibility and adjustability. Although the cost-effectiveness of DBS has been investigated extensively in movement disorders, few economic analyses of DBS for psychiatric disorders exist.
View Article and Find Full Text PDFEvaluation of Inhaled Nitric Oxide Generation Systems at Altitude.
Mil Med
August 2024
Department of Surgery, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA.
Introduction: Inhaled nitric oxide (INO) is a selective pulmonary vasodilator delivered from compressed gas cylinders filled to 2,200 psig (137.8 bar) with 800 ppm of NO in a balance of nitrogen. NO is currently FDA-approved for use in term or near-term infants with hypoxemia and signs of pulmonary hypertension in the absence of cardiac disease.
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