AI Article Synopsis
- Researchers hypothesized that women with lower extremity peripheral arterial disease (PAD) would experience more significant mobility loss and quicker functional decline than men.
- In a study involving 380 PAD patients, outcomes such as the ability to walk for 6 minutes were assessed annually over four years, taking into account factors like age, race, and physical activity.
- Results showed that women were significantly more likely to lose mobility and experience faster declines in walking ability than men, with differences potentially linked to smaller calf muscle area in women.
Article Abstract
Objectives: We hypothesized that women with lower extremity peripheral arterial disease (PAD) would have greater mobility loss and faster functional decline than men with PAD.
Background: Whether rates of mobility loss or functional decline differ between men and women with PAD is currently unknown.
Methods: Three hundred eighty men and women with PAD completed the 6-min walk, were assessed for mobility disability, and underwent measures of 4-m walking velocity at baseline and annually for up to 4 years. Computed tomography-assessed calf muscle characteristics were measured biannually. Outcomes included becoming unable to walk for 6 min continuously among participants who walked continuously for 6 min at baseline. Mobility loss was defined as becoming unable to walk for a quarter mile or to walk up and down 1 flight of stairs without assistance among those without baseline mobility disability. Results were adjusted for age, race, body mass index, physical activity, the ankle brachial index, comorbidities, and other confounders.
Results: At 4 years of follow-up, women were more likely to become unable to walk for 6 min continuously (hazard ratio: 2.30, 95% confidence interval: 1.30 to 4.06, p = 0.004), more likely to develop mobility disability (hazard ratio: 1.79, 95% confidence interval: 1.30 to 3.03, p = 0.030), and had faster declines in walking velocity (p = 0.022) and the distance achieved in the 6-min walk (p = 0.041) compared with men. Sex differences in functional decline were attenuated after additional adjustment for baseline sex differences in calf muscle area.
Conclusions: Women with PAD have faster functional decline and greater mobility loss than men with PAD. These sex differences may be attributable to smaller baseline calf muscle area among women with PAD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077144 | PMC |
| http://dx.doi.org/10.1016/j.jacc.2010.09.042 | DOI Listing |
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