The occurrence of pregnancy in women with chronic kidney disease undergoing dialysis is still uncommon; however, women in this population do become pregnant and need management by renal and high-risk obstetric teams to promote best outcomes. This article discusses recommendations for medical considerations, the dialysis regimen, medications used, medical nutrition therapy, and the assessment of dry weight gain. Most recommendations are based upon case experience.
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Surgical parathyroidectomy in pregnancy for severe secondary hyperparathyroidism associated with end-stage kidney disease.
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Maternity Services, The Royal Women's Hospital, Parkville, Victoria, Australia.
Secondary hyperparathyroidism (SHPT) is common in patients with end-stage kidney disease (ESKD) on kidney replacement therapy, which leads to abnormalities of bone and mineral metabolism. Patients conceiving on kidney replacement therapy add a further layer of complexity to the management of their SHPT. Existing literature in cases of primary hyperparathyroidism (PHPT) has linked untreated hyperparathyroidism to increased maternal and fetal morbidity, including hypertensive disorders of pregnancy, fetal growth restriction and neonatal hypocalcaemia.
View Article and Find Full Text PDFPregnancy Related Acute Kidney Injury: An Exigent Cause of Chronic Kidney Disease in Developing Countries.
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Department of Nephrology, SMS Medical College and Hospital, Jaipur, Rajasthan India.
Background: Development of PRAKI due to various gestation-related complication leads to poor maternal and foetal outcome. The aim of this study was to estimate the prevalence of PRAKI resulting in CKD, associated factors and feto-maternal outcome.
Methods: In this prospective observational study patients with PRAKI requiring ≥ 1 session of haemodialysis were included and followed up for 6 months to assess renal outcomes.
Urinary congophilia as a predictive biomarker of lupus nephritis in pregnant and non-pregnant women with systemic lupus erythematosus.
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View Article and Find Full Text PDFIncreased Serotonin Levels and Unchanged Glutamate and GABA Levels in Thalamic Microdialysates Despite Reduced Cell Numbers in a Valproic Acid-Induced Autism Model.
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School of Medicine, Department of Physiology, Eskisehir Osmangazi University, Eskisehir, 26040, Turkey.
Article Synopsis
- Autism spectrum disorders (ASDs) are neurodevelopmental conditions marked by social skill deficits and abnormal sensory responses, with an imbalance of excitation and inhibition in the brain being a crucial factor.
- This study examined the levels of key neurotransmitters (GABA, glutamate, and serotonin) in the thalamus of rats induced with ASD using valproic acid (VPA) during pregnancy.
- Results showed that ASD rats had higher serotonin levels, altered thalamic volumes, and fewer thalamic neurons and glia compared to the control group, suggesting a disrupted neurotransmitter balance in the thalamus related to ASD.
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