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Comparative analysis of whole cell-derived vesicular delivery systems for photodynamic therapy of extrahepatic cholangiocarcinoma.
J Photochem Photobiol B
May 2024
Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, 314001 Jiaxing, Zhejiang, PR China; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CS Utrecht, the Netherlands; Membrane Biochemistry and Biophysics, Department of Chemistry, Faculty of Science, Utrecht University, 3584 CS Utrecht, the Netherlands. Electronic address:
Article Synopsis
- - This study investigated using bionanovesicles for delivering a photosensitizer drug into cholangiocarcinoma cells to enhance photodynamic therapy (PDT) outcomes.
- - Two types of bionanovesicles were created from cholangiocarcinoma cells, characterized for size, stability, and efficiency, and shown to effectively deliver the photosensitizer with no toxicity associated with dark conditions.
- - The results indicated that these vesicles could successfully disperse the photosensitizer inside tumor cells and achieved higher PDT efficiency compared to traditional methods using liposomal forms.
Guest-Shuttling in a Nanosized Metallobox.
Angew Chem Int Ed Engl
March 2024
Institute of Advanced Materials (INAM), Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universitat Jaume I, Av. Vicente Sos Baynat s/n, Castellón, E-12006, Spain.
An iridium-conjoined long and narrow metallorectangle was obtained by combining a quinoxalinophenanthrophenazine-connected Janus-di-imidazolylidene ligand and pyrazine. The size and shape of this assembly together with the fused polyaromatic nature of its panels provides it with properties that are uncommon for other metallosupramolecular assemblies. For example, this nanosized 'slit-like' metallobox is able show very large binding affinities with planar organic molecules in such a way, that the cavity is asymmetrically occupied by the guest molecule.
View Article and Find Full Text PDFAlthough tris(8-hydroxyquinoline)aluminum (Alq), a fluorescent optical organometallic material, is known for its applications in optoelectronics, it has only few and limited applications in the biological field. In this study, the antibacterial activity of Alq micro and nanostructures was investigated. We prepared Alq nanostructures.
View Article and Find Full Text PDFAn insight into the morphology of DNA compaction induced by homobinuclear Ru(II) polypyridyl complexes.
J Inorg Biochem
September 2022
Bioprospecting Group, Agharkar Research Institute, G. G. Agarkar Road, Pune 411004, India.
Binuclear Ru(II) polypyridyl complexes [Ru(NN)(BIPMB)] (1-4), where N-N = 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), dipyrido [3,2-d:2',3'-f] quinoxaline (dpq), and dipyrido[3,2-a:2',3'-c]phenazine (dppz), have been synthesized using suitable precursors and bridging ligand (BIPMB), where BIPMB = 3,3'-bis-{(imidazol-1-yl)-[4,5-f]-1,10-phenanthroline) methyl}-1,1'-biphenyl. The binding mode and affinity of complexes 1-4 with Calf Thymus DNA (CT-DNA) were determined by absorption and steady-state fluorescence spectroscopy. The decrease in viscosity of CT-DNA on sequential addition of these complexes indicated DNA condensation and the result was corroborated by circular dichroism (CD).
View Article and Find Full Text PDFSynthesis, Spectroscopic, Structural and Molecular Docking Studies of Some New Nano-Sized Ferrocene-Based Imine Chelates as Antimicrobial and Anticancer Agents.
Materials (Basel)
May 2022
Department of Chemistry, Faculty of Science, Sohag University, Sohag 82534, Egypt.
The newly synthesized organometallic acetyl ferrocene imine ligand (HL) was obtained by the direct combination of 2-acetyl ferrocene with 2-aminothiophenol. The electronic and molecular structure of acetyl ferrocene imine ligand (HL) was refined theoretically and the chemical quantum factors were computed. Complexes of the acetyl ferrocene imine ligand with metal(II)/(III) ions (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II)) were fabricated.
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