AI Article Synopsis
- Tumoral necrosis factor alpha (TNFα) blockers effectively treat inflammatory diseases like rheumatoid arthritis and psoriasis, but can sometimes cause psoriasiform lesions in some patients.
- The exact cause of this side effect remains unclear, making treatment challenging.
- A case study reports successful resolution of adalimumab-induced psoriasis in a woman with rheumatoid arthritis and vitamin D deficiency after high doses of vitamin D(3), suggesting a potential link between vitamin D deficiency and this side effect.
Article Abstract
Tumoral necrosis factor alpha blockers are very efficient in the treatment of many inflammatory systemic diseases, including rheumatoid arthritis and psoriasis. However, a paradoxical arouse of psoriasiform lesions may occur in a few patients taking anti-TNFα. The etiology of this rare side effect is still a mystery, and its treatment may be difficult. The authors report the resolution of adalimumab-induced psoriasis in a woman with rheumatoid arthritis after the use of high vitamin D(3) doses for the treatment of vitamin D deficiency. This is the first report of resolution of anti-TNFα-induced psoriasiform lesions by high doses of vitamin D(3) in a patient with rheumatoid arthritis and vitamin D deficiency. This case raises interesting questions on the role of vitamin D deficiency in the pathogenesis of this side effect and on the possible usefulness of high-dose vitamin D(3) in its treatment.
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| http://dx.doi.org/10.1007/s00296-011-1799-9 | DOI Listing |
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