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Application of cryoablation in animal models of bladder and muscle-invasive bladder cancer: a narrative review of current status and future perspectives.
Quant Imaging Med Surg
December 2024
Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, and Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Background And Objective: In patients diagnosed with bladder cancer (BC), muscle-invasive bladder cancer (MIBC) accounts for 25%, including tumors invading the intrinsic muscle layer (T2), surrounding tissues of the bladder (T3), or adjacent pelvic organs/structures (T4). Cryoablation promises to be a novel interventional oncology technique, which effectively induces cellular destruction through freezing and thawing cycles. In addition to the direct tumor-killing effect, it also has a tumor-immune effect.
View Article and Find Full Text PDFKCl enhances the cryoablation-induced antitumor immune response: A hepatocellular carcinoma murine model research.
Cryobiology
December 2024
Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, Shanghai, China; Shanghai Technical Service Platform for Cryopreservation of Biological Resources, Shanghai, China; Shanghai Collaborative Innovation Center for Tumor Treatment with Energy, Shanghai, China. Electronic address:
Cryoablation is a valuable treatment for liver cancer. To investigate the effect of KCl solution on the immunological response post cryoablation, we created a tumor-bearing mice model by subcutaneously implanting Hepal-6 cells in adult Balb/c mice. Subsequently, the mice were randomly assigned to three groups: group A (sham cryoablation), group B (cryoablation), and group C (cryoablation plus KCl solution).
View Article and Find Full Text PDFImmunotherapy in Basal Cell Carcinoma.
J Clin Med
September 2024
Department of Dermatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Basal cell carcinoma (BCC) is the most frequent of all cancers, with an increasing incidence. The first line therapy is surgical excision, but topical therapies can be used in low-risk superficial BCCs, while the more advanced, unresectable, or metastatic BCCs benefit from systemic therapies with hedgehog inhibitors and immunotherapy. The purpose of this review is to highlight local and systemic immunotherapies and their efficacy in the management of BCCs.
View Article and Find Full Text PDFLentigo maligna: a comprehensive review on diagnosis and treatment.
Ital J Dermatol Venerol
August 2024
Dermatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain -
Article Synopsis
- Lentigo maligna (LM) is a type of melanoma in situ that usually develops on sun-damaged skin, appearing as a slow-growing patch, making it tricky to diagnose and treat.
- While LM generally has a good prognosis, it can invade the dermis and behave like invasive melanoma, making surgical removal the primary treatment option.
- New methods such as margin-controlled surgery and image-guided treatments are being explored, alongside other non-surgical options, to better manage LM/LMM and address the challenges of treating lesions in sensitive areas.
Nanoemulsions in Skin Cancer Therapy: A Promising Frontier.
Curr Pharm Biotechnol
July 2024
S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, 384012, India.
Article Synopsis
- - Skin cancer, particularly prevalent among white individuals, includes different types such as malignant melanoma, basal, and squamous cell carcinoma, requiring various advanced treatments like electrochemotherapy and surgical techniques.
- - Nanotechnology, specifically nanoemulsion, is emerging as a promising method for delivering cancer-fighting drugs directly to tumors, enhancing the effectiveness and reducing side effects of treatment.
- - Despite its potential, research on nanoemulsion for treating skin cancer is mostly in preclinical stages, as factors within the body limit its ability to penetrate the skin effectively.
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