[The effect of preoperative radiotherapy using high-energy radiation on the pathomorphosis of kidney cancer].

The paper analyses the effect produced by some preoperative treatments on the degree and depth of tumor cell lesion in 5 groups of patients with renal cell carcinoma. Group 1 consisted of 80 patients who had a surgical treatment alone and were studied for natural pathomorphism. Group 2 comprised 250 patients who had preoperative large-fractional radiation therapy in a total dose of 20 Gy. There was a partial suppression of mitotic and amitotic activities, more profound changes in organellae, particularly in mitochondria, nucleus, nucleolus, even destruction of individual cell elements as compared to the control group. Group 3 included 110 patients who had preoperative superfractional radiation therapy in a total dose of 14 Gy. The therapeutic pathomorphism of renal cell carcinoma was characterized by more profound and extensive changes in tumor cells as compared to Group 2. Group 4 involved 10 patients who underwent renal artery embolization. The letter led to the similar changes in tumor tissue as in Group 2. Particularly marked and extensive dystrophic and necrotic changes in tumor cells were observed in 35 patients who were enrolled into Group 5 and had preoperative renal artery embolization in combination with superfractional radiation therapy. The preoperative treatment techniques failed, however, to cause a total tumor parenchymal death as depending on the mode of preoperative therapy, the slightly damaged tumor cells were revealed in greater or lower quantities.