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Deciphering the Prognostic Landscape of Esophageal Adenocarcinoma: A PANoptosis-Related Gene Signature.
J Cancer
January 2025
Department of Pathology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China.
Esophageal adenocarcinoma (EAC) remains a challenging malignancy with low survival rates despite advances in treatment. Understanding the molecular mechanisms and identifying reliable prognostic markers are crucial for improving clinical outcomes. We conducted a comprehensive bioinformatics analysis utilizing TCGA, GTEx, and GEO datasets to identify PANoptosis-related genes (PRGs) associated with EAC.
View Article and Find Full Text PDFProbing Temperature Changes Using Nonradiative Processes in Hyperbolic Meta-Antennas.
ACS Appl Opt Mater
December 2024
Department of Physics, Umeå University, Linnaeus väg 24, 901 87 Umeå, Sweden.
Multilayered metal-dielectric nanostructures display both a strong plasmonic behavior and hyperbolic optical dispersion. The latter is responsible for the appearance of two separated radiative and nonradiative channels in the extinction spectrum of these structures. This unique property can open plenty of opportunities toward the development of multifunctional systems that simultaneously can behave as optimal scatterers and absorbers at different wavelengths, an important feature to achieve multiscale control of light-matter interactions in different spectral regions for different types of applications, such as optical computing or detection of thermal radiation.
View Article and Find Full Text PDFEnhanced Bone Regeneration by Schwann Cells through Coupling of Osteogenesis and Angiogenesis via β-catenin signaling in a Preclinical Model of Distraction Osteogenesis.
Int J Med Sci
January 2025
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The lengthy period of external fixation for bone consolidation increases the risk of complications during distraction osteogenesis (DO). Both pro-angiogenic and osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) contribute to bone regeneration during DO. The underlying mechanism of Schwann cells (SCs) in promoting bone regeneration during DO remains poorly understood.
View Article and Find Full Text PDFMonitoring of the trough concentration of valproic acid in pediatric epilepsy patients: a machine learning-based ensemble model.
Front Pharmacol
December 2024
Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Aims: Few personalized monitoring models for valproic acid (VPA) in pediatric epilepsy patients (PEPs) incorporate machine learning (ML) algorithms. This study aimed to develop an ensemble ML model for VPA monitoring to enhance clinical precision of VPA usage.
Methods: A dataset comprising 366 VPA trough concentrations from 252 PEPs, along with 19 covariates and the target variable (VPA trough concentration), was refined by Spearman correlation and multicollinearity testing (366 × 11).
Transgenic Cynodon dactylon overexpressing CdPIF4 alters plant development and cold stress tolerance.
Physiol Plant
January 2025
Coastal Salinity Tolerant Grass Engineering and Technology Research Center, Ludong University, Yantai, China.
Bermudagrass [Cynodon dactylon (L.) Pers.] is widely used for soil remediation, livestock forage, and as turfgrass for sports fields, parks, and gardens due to its resilience and adaptability.
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