Collapsing glomerulopathy in a girl with systemic lupus erythematosus.

Pediatr Nephrol

Histopathology Department, St. Thomas' Hospital, Guy's and St Thomas' NHS Trust, London, UK.

Published: May 2011

Collapsing glomerulopathy has increasingly been recognised in patients with conditions other than HIV. The non-HIV form of collapsing glomerulopathy generally shows little response to standard therapies. We describe a 12-year-old girl with a pre-existing diagnosis of systemic lupus erythematosus presenting with renal failure. A renal biopsy gave the histological diagnosis of collapsing glomerulopathy with evidence of "full-house" immunostaining. We propose collapsing glomerulopathy in her case, as no other cause was found was secondary to systemic lupus erythematosus. The immunophenotype of her podocytes suggested a partial de-differentiation that might have been important in her partial response to immunosuppression.

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Source
http://dx.doi.org/10.1007/s00467-010-1756-yDOI Listing

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