AI Article Synopsis
- T cell progenitors migrate through the thymus, navigating complex environments in their educational process.
- Recent research has shown their movement patterns but lacks clarity on the factors influencing this dynamic behavior.
- Our study reveals that thymocytes move along stromal cell networks, which not only serve as pathways for migration but also support dendritic cell attachment, emphasizing the importance of thymic structure in T cell development.
Article Abstract
After entry into thymus, T cell progenitors migrate in the cortex and the medulla while completing their education. Recent reports have documented the dynamic and tortuous behavior of thymocytes. However, other than chemokines and/or segregated thymic substrates, the factors contributing to the dynamic patterns of thymocyte movement are poorly characterized. By combining confocal and dynamic two-photon microscopy, we demonstrate that thymocytes continuously migrate on thymic stromal cell networks. In addition to constituting "roads" for thymocytes, we observed that these networks also provide a scaffold on which dendritic cells attach themselves. These results highlight the central role of stromal microanatomy in orchestrating the multiple cellular interactions necessary for T cell migration/development within the thymus.
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| http://dx.doi.org/10.4049/jimmunol.1003563 | DOI Listing |
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