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Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat. | LitMetric

AI Article Synopsis

  • The study investigates the link between anxiety and depression using a chronic unpredictable stress (CUS) model in adult rats, which simulates depressive-like behaviors.* -
  • Results showed that while stress led to changes in weight gain and increased activity, it did not produce measurable anxiety-like behaviors in the rats.* -
  • Hormonal and neurochemical analyses revealed a relationship between stress-induced corticosterone levels and serotonin activity in the hypothalamus, indicating that the effects of stress may be more closely tied to depression rather than anxiety immediately after stress exposure.*

Article Abstract

The high comorbidity of anxiety and depression suggests a potential degree of commonality in their etiologies. The chronic unpredictable stress (CUS) model effectively replicates depressive-like phenotypes; however, the ability of CUS to produce anxiety-like behaviors has not been adequately addressed. Using the CUS paradigm (2 stressors per day for 10 days) in adult Sprague-Dawley rats we identified behavioral, hormonal, and neurochemical changes one day after the cessation of treatment. Stress attenuated weight gain throughout the study and increased locomotor activity one day after treatment, but had no effect on anxiety-behavior as measured by the elevated plus maze. In addition, plasma corticosterone levels were positively correlated with hypothalamic serotonin (5-HT) activity one day after stress treatment as determined by the ratio of the metabolite 5-hydroxyindoleacetic acid (5-HIAA) to the parent compound (5-HIAA/5-HT ratio). These data suggest behavioral phenotypes associated with depression, but not comorbid anxiety, emerge in the immediate period after cessation of stress and that stress related physiology is related to 5-HT activity in the hypothalamus.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064719PMC
http://dx.doi.org/10.1016/j.bbr.2011.01.038DOI Listing

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