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Comprehensive and Efficient Assessment of Psychological Flexibility in the Context of Chronic Pain.
Eur J Pain
February 2025
Department of Psychology, Uppsala University, Uppsala, Sweden.
Background: The Multidimensional Psychological Flexibility Inventory (MPFI) is a measure of all facets of psychological flexibility and inflexibility, potentially important processes of change in psychological treatment for chronic pain. In some contexts, it can be considered too long. The aim of this study was, therefore, to validate a short form MPFI (MPFI-24P) in a chronic pain sample.
View Article and Find Full Text PDFDeep analysis of the major histocompatibility complex genetic associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS.
BMC Immunol
January 2025
Laboratoire Génomique, Bioinformatique, et Chimie Moléculaire, Conservatoire National des Arts et Métiers, 2 rue Conté 75003, Paris, EA7528, France.
Introduction: We have reanalyzed the genomic data from the International Collaboration for the Genomics of HIV (ICGH), focusing on HIV-1 Elite Controllers (EC).
Methods: A genome-wide association study (GWAS) was performed, comparing 543 HIV-1 EC individuals with 3,272 uninfected controls (CTR) of European ancestry. 8 million single nucleotide polymorphisms (SNPs) and HLA class I and class II gene alleles were imputed to compare EC and CTR.
A smart cascade theranostic prodrug system activated by hydrogen peroxide for podophyllotoxin delivery.
J Mater Chem B
January 2025
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
The construction of selectively activated prodrugs serves as a crucial strategy for reducing the adverse effects associated with disease treatment. Cascade self-assembled visual prodrugs have been applied to the construction of selective activated prodrugs with low background interference and fluorescence. In this work, we rationally designed an anticancer theranostic prodrug (CM-PPT) consisting of an anticancer drug podophyllotoxin, a fluorescent dye precursor, and an HO trigger boronate ester group, which could be activated by HO oxidation, thereby releasing active anticancer molecules and forming fluorescent fragments concurrently.
View Article and Find Full Text PDFAn esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment.
Mater Today Bio
February 2025
Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, China.
Esophageal cancer is the eighth most common cancer worldwide and the sixth leading cause of cancer-related deaths. In this study, we propose a novel esophageal stent equipped with a wireless, battery-free, and movable photodynamic therapy (PDT) unit designed to treat esophageal tumors with flexibility, precision, and real-time control. This system integrates a PDT unit and an electrochemical pneumatic soft actuator into a conventional esophageal stent.
View Article and Find Full Text PDFRecovery and purification of acetic acid from extremely diluted solutions using a mixed bed ion exchange resin - technical feasibility.
RSC Adv
January 2025
TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de San Sebastián Mikeletegi Pasealekua 2 20009 Donostia-San Sebastián Spain +34 944 041 445 +34 946 430 850.
A downstream process for the recovery and purification of acetic acid (AA) from an extremely diluted solution (100 mg L) also containing a mixture of contaminating inorganic salts in the form of bicarbonates, phosphates, sulfates and chlorides (DPM medium) has been developed, showing its technical feasibility. The process involves two successive steps based on the use of a mixed bed ion exchange (IEX) resin. The first step, a demineralization treatment to remove the inorganic anions that could potentially interfere with the recovery and purification of AA, involves a combined treatment of calcium precipitation, acidification with the Amberlite IR-120 resin and treatment with the Amberlite MB20 mixed bed resin.
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