AI Article Synopsis
- A study was conducted to analyze the types and drug resistance of Streptococcus pneumoniae in Chinese children under 5 with pneumonia, involving 3,865 participants and 338 bacterial samples.
- The most common serotypes identified were 19F, 19A, 23F, 6B, and 14, with PCV7, PCV10, and PCV13 potentially covering a significant portion of these strains.
- Only 1.8% of the isolates were penicillin-resistant, but nearly all were resistant to erythromycin, highlighting the high drug resistance of serotype 19A and suggesting that PCV13 would be more effective in preventing disease due to its coverage of this serotype.
Article Abstract
A prospective study was performed to determine serotype distribution and antimicrobial resistance in Streptococcus pneumoniae (S. pneumoniae) from Chinese children <5 years old meeting pneumonia criteria. A total of 3865 children were enrolled and 338 S. pneumoniae isolates were obtained. The most frequent serotypes were 19F (55.6%), 19A (13.9%), 23F (10.1%), 6B (4.7%), and 14 (3.6%). The 7-, 10- and 13-valent conjugate vaccines, respectively, covered 76.3%, 76.9%, and 92.3% of isolates. Out of the isolates, six (1.8%) were penicillin resistant. All except 1 of the isolates were resistant to erythromycin. Serotype 19A showed the highest drug resistance. The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A.
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