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Preventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice.
NPJ Sci Food
December 2024
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka, Japan.
In a series of studies on blood-brain barrier transportable peptides, a soybean dipeptide, Tyr-Pro, penetrated the mouse brain parenchyma after oral intake and improved short and long memory impairment in acute Alzheimer's model mice. Here, we aimed to clarify the anti-dementia effects of this peptide administered to SAMP8 mice prior to dementia onset. At the end of the 25-week protocol in 16-week-old SAMP8 mice, Tyr-Pro (10 mg/kg/day) significantly improved the reduced spatial learning ability compared with that in the control and amino acid (Tyr + Pro) groups as indicated by the results of Morris water maze tests conducted for five consecutive days.
View Article and Find Full Text PDFDifferential effects of fine particulate matter constituents on acute coronary syndrome onset.
Nat Commun
December 2024
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China.
Fine particulate matter has been linked with acute coronary syndrome. Nevertheless, the key constituents remain unclear. Here, we conduct a nationwide case-crossover study in China during 2015-2021 to quantify the associations between fine particulate matter constituents (organic matter, black carbon, nitrate, sulfate, and ammonium) and acute coronary syndrome, and to identify the critical contributors.
View Article and Find Full Text PDFAcute Psychosis as Presenting Symptoms of Vitamin B12 Deficiency: A Case Series.
Cureus
November 2024
Internal Medicine, Tata Main Hospital, Jamshedpur, IND.
Background: Vitamin B12 deficiency is a prevalent condition affecting a significant proportion of India's population, with implications for mental health. Despite its established link to psychiatric symptoms, vitamin B12 deficiency often remains underdiagnosed. The aim of this study is to highlight the association between vitamin B12 deficiency and acute psychosis, emphasizing the importance of early detection and treatment.
View Article and Find Full Text PDFA Rare Case Report of Dengue Fever Presenting With Acute Leukoencephalopathy With Restricted Diffusion.
Cureus
November 2024
Radiodiagnosis, Sir Takhtasinhji General Hospital, Bhavnagar, IND.
Acute leukoencephalopathy with restricted diffusion (ALERD) is an emerging clinico-radiological syndrome marked by sudden onset encephalopathy and characteristic restricted diffusion in the subcortical white matter on MRI. While typically linked to other viral etiologies, its association with dengue fever is not well known and is rarely documented in the literature. In this report, we describe a rare case of ALERD associated with dengue fever in a young patient, emphasizing clinical features, neuroimaging findings, management, and outcome.
View Article and Find Full Text PDFAssociations of NETs with inflammatory risk and clinical predictive value in large artery atherosclerosis stroke: a prospective cohort study.
Front Immunol
December 2024
Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background And Objective: Neutrophil extracellular traps (NETs) with inflammatory risk are important contributors to cardiovascular disease, but no definitive information is available in large artery atherosclerotic (LAA) stroke. This study aims to investigate the association between NETs with related inflammatory biomarkers and prognosis of LAA stroke in the Chinese population.
Methods: A prospective study involving 145 LAA stroke cases and 121 healthy controls was conducted.
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