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Alzheimers Dement
December 2024
Karolinska Institutet, Solna, Sweden.
Background: High age is the biggest risk factor for Alzheimer's disease (AD). Approved drugs that slow down the aging process have the potential to be repurposed for the primary prevention of AD. The aim of our project was to use a reverse translational approach to identify such drug candidates in epidemiological data followed by validation in cell-based models and animal models of aging and AD.
View Article and Find Full Text PDFJ Perinat Med
December 2024
Department of Obstetrics and Gynecology, 26447 Peking University First Hospital, Beijing, China.
Objectives: To investigate the perinatal outcomes of SR using radiofrequency ablation (RFA) in MC pregnancies, identified factors affecting these outcomes, and assessed the associated learning curve.
Methods: This retrospective cohort study included all consecutive MC pregnancies that required RFA from September 2013 to April 2023 at our institution. The perinatal outcomes were compared on the basis of various indications, and binary logistic regression analysis was performed to identify the risk factors for cotwin loss.
The orthodontic management of patients with Class III malocclusion poses numerous treatment challenges. Various removable, fixed, orthopedic, and myofunctional appliances have been recommended for its correction. The Reverse Twin Block is a removable appliance which has been used for the early management of such cases.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy.
Twin pregnancies are at increased risk of morbidity and mortality compared to singletons. Among all twins, monochorionic pregnancies are at higher risk of specific and non-specific complications compared to dichorionic pregnancies. Therefore, it is of great importance to properly counsel future parents with monochorionic pregnancies regarding the risks of adverse outcomes and the modalities of monitoring and intervention of the potential complications.
View Article and Find Full Text PDFPrenat Diagn
December 2024
Department of Gynecology and Obstetrics, Center for Fetal Therapy, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Objectives: Umbilical artery Doppler intermittent absent and reversed end-diastolic flow (iAREDF) is associated with increased perinatal morbidity and mortality in monochorionic twins with selective fetal growth restriction. The clinical significance of umbilical artery iAREDF in appropriately grown monochorionic twins is not well described.
Methods: This is a single-institution retrospective cohort study describing characteristics and outcomes of monochorionic diamniotic twins with appropriate for gestational age growth and umbilical artery iAREDF in comparison to monochorionic diamniotic twins with selective fetal growth restriction and iAREDF, or sFGR type III.
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