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We present a case of fatal carbamazepine poisoning. Quantitative analysis of carbamazepine using high performance liquid chromatography, revealed that the concentrations of carbamazepine were 50.2 microg/ml in the femoral venous blood and 60.3 microg/ml in the heart blood, respectively, and many unabsorbed tablets were also observed in the stomach contents. We concluded that the cause of death was due to carbamazepine overdose.
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Article Synopsis
- Carbamazepine overdose can lead to dose-dependent toxicity, with serious effects typically observed at doses above 200 mg/kg, contrary to the common belief that severe toxicity starts at >50 mg/kg.
- A study analyzed 42 patients who ingested over 2,000 mg of carbamazepine, finding that severe clinical effects like coma, seizures, and hypotension were rare in those who ingested less than 200 mg/kg.
- The findings suggest that relying on the 50 mg/kg threshold for classifying severe toxicity is excessive, as significant risks only appear at higher doses.
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