AI Article Synopsis
- Exhaustive physical exercise in rats caused damage to lysosomes in the liver, heart, and skeletal muscle, leading to tissue necrosis and the release of hydrolases into the bloodstream.
- In patients with hypertrophic cardiomyopathy, stepwise physical loading resulted in the release of lysosomal enzymes into the blood, unlike in healthy individuals.
- The severity of the disease correlates with a higher concentration of these enzymes found in the patients' circulation.
Article Abstract
Impairments in structural integrity of liver, heart and skeletal muscle lysosomes followed by necrotic and necrobiotic alterations in the tissues and secretion of active hydrolases in blood were detected under conditions of exhaustive physical exercises in rats when dose-dependent physical loading was studied. At the same time, in patients with hypertrophic cardiomyopathy physical loading, carried out as stepwise spiroveloergometry up to the submaximal heart rate, led to release of lysosomal enzymes into blood, which was not observed in healthy persons under similar conditions. The higher level of enzymes was found in circulation of the patients with most severe forms of the disease.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Inherent CeO Pore Structure Confined Pd for the Catalytic Performance Regulation.
ACS Appl Mater Interfaces
January 2025
School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
In this study, we synthesized CeO possessing an open pore structure and verified its structural differences compared to CeO lacking such an open pore structure. Using these two CeO samples as catalyst supports and loading them with Pd metals, a series of characterizations were carried out on the resultant catalysts to analyze their structures and properties meticulously. We have elucidated the influence of the open pore structure on the loading position of Pd.
View Article and Find Full Text PDFNew PPARα Agonist A190-Loaded Microemulsion for Chemotherapy-Induced Peripheral Neuropathy.
Mol Pharm
January 2025
Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of anticancer agents with limited effective preventive or therapeutic interventions. Although fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist, has demonstrated neuroprotective and analgesic properties, its clinical utility is hindered by low receptor affinity, poor subtype selectivity, and suboptimal bioavailability. A190, a highly selective and potent nonfibrate PPARα agonist, offers a promising alternative but is limited by poor aqueous solubility, resulting in reduced oral bioavailability and therapeutic efficacy.
View Article and Find Full Text PDFNeuro-computational simulation of blood flow loaded with gold and maghemite nanoparticles inside an electromagnetic microchannel under rapid and unexpected change in pressure gradient.
Electromagn Biol Med
January 2025
Department of Mathematics, University of Gour Banga, Malda, India.
In cardiovascular research, electromagnetic fields generated by Riga plates are utilized to study or manipulate blood flow dynamics, which is particularly crucial in developing treatments for conditions such as arterial plaque deposition and understanding blood behavior under varied flow conditions. This research predicts the flow patterns of blood enhanced with gold and maghemite nanoparticles (gold-maghemite/blood) in an electromagnetic microchannel influenced by Riga plates with a temperature gradient that decays exponentially, under sudden changes in pressure gradient. The flow modeling includes key physical influences like radiation heat emission and Darcy drag forces in porous media, with the flow mathematically represented through unsteady partial differential equations solved using the Laplace transform (LT) method.
View Article and Find Full Text PDFDevelopment of functionalized biochar composites for enhanced boron adsorption from aqueous solutions.
Heliyon
January 2025
Department of Soil Science, Faculty of Agriculture, University of Jiroft, Jiroft, 7867161167, Iran.
This study focuses on developing biochar-based adsorbents with high adsorption capacity and rapid adsorption rates for removing boron from aqueous solutions. Hydroxy-enriched biochar composites (BC (carboxylated biochar), BC-PDA (polydopamine loaded biochar), MBC-PDA (polydopamine loaded magnetic biochar), BC-AlOOH (AlOOH loaded biochar), and BC-ZnCl (biochar modified by ZnCl)) were synthesized specifically for boron adsorption to utilize the superior adsorption capacity of biochar. All adsorbents were synthesized using straightforward experimental techniques from date palm cellulosic fibers as promising lignocellulose feedstock and subjected to various characterization methods.
View Article and Find Full Text PDFPhysical scaling for predicting shear viscosity and memory effects of lithium-ion battery cathode slurries.
Soft Matter
January 2025
Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, 60208, USA.
Lithium-ion battery cathodes are manufactured by coating slurries, liquid suspensions that typically include carbon black (CB), active material, and polymer binder. These slurries have a yield stress and complex rheology due to CB's microstructural response to flow. While optimizing the formulation and processing of slurries is critical to manufacturing defect-free and high-performance cathodes, engineering the shear rheology of cathode slurries remains challenging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!