A six step synthesis of (±)-7-hydroxylycopodine has been achieved in 5% overall yield. In the key step, a Prins cyclization of a bicyclic keto alkyne in 60% H(2)SO(4) forms a tricyclic dihydroxy amino ketone.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056437 | PMC |
| http://dx.doi.org/10.1021/ol200119h | DOI Listing |
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