Objective: To assess the therapeutic effect of Qufengtongluo (QFTL) recipe against proteinuria and glomerular filtration membrane damage in rats with adriamycin-induced nephropathy (AN).
Methods: Fifty-six SD rats were randomized into normal control (A) and AN model groups. In the AN model group, the rat AN models established by a single intravenous injection of adriamycin via the tail vein were subdivided into model (B), QFTL recipe (C), prednisone (D), and benazepril (E) groups 3 weeks after adriamycin injection. The 24-h urinary protein level was measured and the expression of anionic sites on the filtration membrane was evaluated using electron microscope with PEI staining. Nephrin expression on the glomerular filtration membrane was detected with indirect immunofluorescence assay.
Results: Compared with group A, the model group showed significantly increased level of 24-h urinary protein (P<0.01), suggesting successful establishment of the AN model. Treatment with QFTL recipe obviously lowered the 24-h urinary protein (P<0.01), and increased the expression of anionic sites and nephrin on the glomerular filtration membrane in the AN rats (P<0.01).
Conclusion: QFTL recipe can effectively decrease 24-h urinary protein, improve the symptoms, and up-regulate the expressions of anionic sites and nephrin on the glomerular filtration membrane in rats with AN.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Gravity-Driven Membrane Filtration with Passive Hydraulic Fouling Control for Drinking Water Treatment: Demonstration of Long-Term Performance at Full Scale.
ACS ES T Water
January 2025
Department of Civil Engineering, The University of British Columbia, 6250 Applied Sciences Lane, Vancouver, British Columbia V6T 1Z4, Canada.
The present study evaluated the performance of a full-scale gravity-driven membrane filtration system with passive hydraulic fouling control (PGDMF) for drinking water treatment in a small community over a 3-year period. The PGDMF system consistently met the design flow and regulated water quality/performance parameters (i.e.
View Article and Find Full Text PDFEffects of magnetotactic bacteria (MTB) on membrane fouling control in an ultrafiltration treatment of chromium-containing surface water.
Water Sci Technol
January 2025
School of Civil Engineering and Architecture, University of Jinan, Jinan 250022, China E-mail:
Ultrafiltration membranes are widely used in the treatment of surface water. However, membrane fouling is a core issue that needs to be addressed in its application. Magnetotactic bacteria (MTB) show early film-forming and magnetotactic behaviour in the presence of external magnetic fields.
View Article and Find Full Text PDFBilayer nanographene reveals halide permeation through a benzene hole.
Nature
January 2025
Institut für Organische Chemie, Universität Würzburg, Würzburg, Germany.
Graphene is a single-layered sp-hybridized carbon allotrope, which is impermeable to all atomic entities other than hydrogen. The introduction of defects allows selective gas permeation; efforts have been made to control the size of these defects for higher selectivity. Permeation of entities other than gases, such as ions, is of fundamental scientific interest because of its potential application in desalination, detection and purification.
View Article and Find Full Text PDFThe use of green synthesized TiO/MnO nanoparticles in solar power membranes for pulp and paper industry wastewater treatment.
Sci Rep
January 2025
Physics Department, Faculty of Science, Cairo University, Giza, 12613, Egypt.
The pulp and paper manufacturing wastewater is as complicated as any other industrial effluent. A promising approach to treating water is to combine photocatalysis and membrane processes. This paper demonstrates a novel photocatalytic membrane technique for solar-powered water filtration.
View Article and Find Full Text PDFApelin-13 inhibits ischemia-reperfusion mediated podocyte apoptosis by reducing m-TOR phosphorylation to enhance autophagy.
FASEB J
January 2025
Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Beijing, China.
Podocytes are essential to maintain the normal filtration function of glomerular basement membrane, which could be injured by ischemia-reperfusion. As complicated function of autophagy in terminal differentiated podocytes, autophagy dysfunction might contribute to I/R induced renal dysfunction following glomerular filtration membrane (GFM) injuries. Meanwhile, apelin-13, an endogenous polypeptide, has been proved to be effective in regulating autophagy and apoptosis in podocytes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!