A variety of active agents increasing [Ca2+]i in cultivated skeletal myocytes have been investigated. It was shown that, out of the agents such as noradrenaline, carbacholine, caffeine, cyclopiazonic acid, and potassium solution, only the last caused the formation of slow calcium waves in skeletal myocytes. These waves propagated not only near the location of the cell nucleus but also along the whole length of myocytes. It is supposed that this wave process can be related to the modulation of excitation-relaxation processes in skeletal muscles.
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