Effects of verapamil and cimetidine were studied on smooth muscle of rat stomach by using an isolated fundus strip preparation. Verapamil 0.5 microgram/ml significantly (P less than 0.001) reduced acetylcholine (Ach) induced contractions of rat stomach fundus strip. The inhibition was very prolong and dose dependent. On the other hand cimetidine 60 micrograms/ml significantly (P less than 0.001) potentiated the Ach-induced contractions, potentiation was dose related. The spontaneous contractions of stomach strip were completely abolished by 8 micrograms/ml verapamil, whereas 1000 micrograms/ml cimetidine had no effect. It was concluded that verapamil given for cardiovascular disorders would also supplement relief of pain from peptic ulcer and might prevent stress ulcer formation.
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