Assessment of endurance exercise training in hepatic endoplasmic reticulum stress.

Hepatic endoplasmic reticulum (ER) stress has recently been associated with several health complications such as obesity, type 2 diabetes, and hepatic steatosis. Exercise training has been recognized for many years to have important beneficial effects in these metabolic complications, however much remains unknown regarding the effects of exercise training on ER stress in the liver. A better understanding of the effects of exercise training on hepatic ER stress response requires studies in which the exercise training protocol is well assessed. Therefore, the purpose of this chapter is to provide detailed description of an endurance-training program and suggest a dietary approach in order to help induce and study changes in ER stress molecular markers expression levels in the liver of rats in response to exercise training.