Tris(trimethylsilyl)silane and azobis(cyclohexanenitrile) promoted the easy intramolecular arylation of aryl bromopyridine carbamates through a radical [1,6] ipso substitution process. These substrates showed a preference for this type of reaction over the alternative [1,7] addition. The results were rationalized by making use of quantum mechanical calculations and computer graphics.

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo102122hDOI Listing

Publication Analysis

Top Keywords

quantum mechanical
8
mechanical calculations
8
unusual approach
4
approach 3-aryl-2-aminopyridines
4
3-aryl-2-aminopyridines radical
4
radical mechanism
4
mechanism synthesis
4
synthesis theoretical
4
theoretical rationale
4
rationale quantum
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!