Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00004424-199009001-00027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Radiological Assessment and Therapeutic Evaluation in Hepatocellular Carcinoma: Differentiation and Treatment Response with Japanese Guidelines.
Cancers (Basel)
December 2024
Department of Radiology, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
The liver is supplied by a dual blood flow system consisting of the portal vein and hepatic artery. Imaging techniques for diagnosing hepatocellular carcinoma (HCC) have been developed along with blood flow imaging, which visualizes the amount of arterial and portal blood flow. The diagnosis of HCC differentiation is important for early-stage liver cancer screening and determination of treatment strategies.
View Article and Find Full Text PDFThe Clinical Utility of Liver-Specific Ultrasound Contrast Agents During Hepatocellular Carcinoma Imaging.
Ultrasound Med Biol
December 2024
Advice-US, Lyon, Auvergne-Rhône Alpes, France.
Hepatocellular carcinoma (HCC) is the most common form of hepatic malignancy, with high mortality rates recorded globally. Early detection through clinical biomarkers, medical imaging and histological assessment followed by rapid intervention are integral for positive patient outcomes. Although contrast-enhanced computed tomography scans and magnetic resonance imaging are recognised as the reference standard for the diagnosis and staging of HCC in international guidelines, ultrasound (US) examination is recommended as a screening tool for patients at risk.
View Article and Find Full Text PDFCharacteristics of chemically induced liver progenitors derived from a pig model of metabolic dysfunction-associated steatotic liver disease.
PLoS One
December 2024
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Article Synopsis
- The study focused on chemically induced liver progenitors (CLiP) derived from steatotic livers in miniature pigs to assess their potential for future liver disease treatment.
- CLiP from steatotic livers showed a higher ability to proliferate compared to those from healthy livers, but only the normal group demonstrated mature liver cell functionality after re-differentiation.
- Despite the lower production of extracellular vesicles (EVs) in the disease group, the overall findings suggest that CLiP from steatotic livers could be a viable option for cell therapy in liver disease patients.
PNPLA3(148M) is a gain-of-function mutation that promotes hepatic steatosis by inhibiting ATGL-mediated triglyceride hydrolysis.
J Hepatol
November 2024
Department of Molecular Genetics, University of Texas Southwestern Medical Center (UTSW), Dallas, TX 75390-9046, USA; Howard Hughes Medical Institute, UTSW, Dallas, TX 75390, USA; The Eugene McDermott Center for Human Growth and Development, UTSW, Dallas, TX, 75390, USA. Electronic address:
Background & Aims: PNPLA3(148M) (patatin-like phospholipase domain-containing protein 3) is the most impactful genetic risk factor for steatotic liver disease (SLD). A key unresolved issue is whether PNPLA3(148M) confers a loss- or gain-of-function. Here we test the hypothesis that PNPLA3 causes steatosis by sequestering ABHD5 (α/β hydrolase domain-containing protein 5), the cofactor of ATGL (adipose TG lipase), thus limiting mobilization of hepatic triglyceride (TG).
View Article and Find Full Text PDFContext-Dependent Distinct Roles of SOX9 in Combined Hepatocellular Carcinoma-Cholangiocarcinoma.
Cells
August 2024
Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) is a challenging primary liver cancer subtype with limited treatment options and a devastating prognosis. Recent studies have underscored the context-dependent roles of SOX9 in liver cancer formation in a preventive manner. Here, we revealed that liver-specific developmental elimination using (LKO) and -based tumor-specific acute elimination (CKO) in SB-HDTVI-based (AY) and (AN) cHCC-CCA models showed contrasting responses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!