AI Article Synopsis
- Dietary fat composition, specifically the presence of ω-6 and ω-3 fatty acids, influences colon tumor development, with ω-6 promoting and ω-3 inhibiting tumor growth in rats.
- In a study comparing canola oil (rich in ω-3) and corn oil (rich in ω-6), canola oil significantly reduced tumor incidence and multiplicity in Fischer rats.
- The lower expression of COX-2 in the colon tissues of rats fed canola oil suggests a potential mechanism for its chemopreventive effects against colon cancer.
Article Abstract
Fatty acid composition of dietary fat plays a vital role in colon tumor development in animal models. Fats containing ω-6 fatty acids (e.g., corn oil) enhanced and ω-3 fatty acids (e.g., flaxseed oil) reduced chemically induced colon tumor development in rats. The objective of the present investigation was to study the effects of dietary canola oil, a source of ω-3 fatty acid on azoxymethane-induced colon cancer development in Fischer rats and compare with dietary corn oil. Dietary canola oil significantly (P<0.05) decreased colonic tumor incidence and tumor multiplicity as compared to dietary corn oil in rats. Fatty acid analysis showed that corn oil group had higher levels of ω-6 fatty acid levels, whereas the canola oil groups exhibited higher levels of ω-3 fatty acids from the colon and serum samples of rats. For the mechanistic study, COX-2 expression in the colon samples from the canola oil group was significantly lower (P<0.05) as compared to the corn oil group. Taken together, dietary canola oil may be chemopreventive for colon tumor development in Fischer rats as compared to possibly by increasing ω-3 fatty acid levels and decreasing COX-2 levels.
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| http://dx.doi.org/10.1080/01635581.2011.523498 | DOI Listing |
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