The tethered Biginelli condensation between hemiaminal 21 and β-keto ester 22 is reported, leading to a model tricyclic core of the cylindrospermopsin alkaloids.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c0cc05034b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessment of the Effects of Anatoxin-a In Vitro: Cytotoxicity and Uptake.
Toxins (Basel)
December 2024
Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla, Profesor García González 2, 41012 Seville, Spain.
Anatoxin-a (ATX-a) is a cyanotoxin whose toxicological profile has been underinvestigated in comparison to other cyanotoxins such as microcystins (MCs) or cylindrospermopsin (CYN). However, its wide distribution, occurrence, and toxic episodes justify more attention. It is classified as a neurotoxin, but it has also been reported to affect other organs and systems.
View Article and Find Full Text PDFDegradation of Cylindrospermopsin Spiked in Natural Water (Paranoá Lake, Brasília, Brazil) by Fenton Process: A Bench-Scale Study.
Toxins (Basel)
December 2024
Environmental Technology and Water Resources Postgraduate Program, Department of Civil and Environmental Engineering, University of Brasília, Brasília 70910-900, Brazil.
The frequency and intensity of harmful cyanobacterial blooms have increased in the last decades, posing a risk to public health since conventional water treatments do not effectively remove extracellular cyanotoxins. Consequently, advanced technologies such as the Fenton process are required to ensure water safety. The cyanotoxin cylindrospermopsin (CYN) demands special attention, as it is abundant in the extracellular fraction and has a high toxicological potential.
View Article and Find Full Text PDFDesign of a Duplex-to-Complex Structure-Switching Approach for the Homogeneous Determination of Marine Biotoxins in Water.
Toxins (Basel)
November 2024
Department of Chemistry, Alfaisal University, Al Zahrawi Street, Al Maather, Al Takhassusi Rd, Riyadh 11355, Saudi Arabia.
In this report, we describe a fluorescent assay for the detection of six marine toxins in water. The mechanism of detection is based on a duplex-to-complex structure-switching approach. The six aptamers specific to the targeted cyanotoxins were conjugated to a fluorescent dye, carboxyfluorescein (FAM).
View Article and Find Full Text PDFPhotonic Aptasensor Based on the Smart Cholesteric Liquid Crystal Network Structure for Cylindrospermopsin Detection.
Anal Chem
December 2024
Department of Chemistry, College of Science, Alfaisal University, Riyadh 11533, Kingdom of Saudi Arabia.
Solid-state cholesteric liquid crystals (CLC) with one-dimensional photonic structure offer a promising platform for constructing chemical and biological optical sensors, owing to their facile fabrication, signal readout, and sensitive and selective responsiveness to target analytes. In this study, we designed a CLC photonic structure intertwined with an interpenetrating polymeric network (IPN) immobilized with a cylindrospermopsin aptamer (CY9) for the selective detection of the cylindrospermopsin toxin (CYT) in water. Upon exposure to CYT, it induced a blue shift in the color of the IPN biosensor chip.
View Article and Find Full Text PDFBloom-forming planktonic Microcystis and benthic Oscillatoria-induced oxidative stress and inflammatory responses in juvenile silver carp and bighead carp.
Toxicon
January 2025
Key Laboratory of Lake and Watershed Science for Water Security, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, China; State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, China.
As global warming and water eutrophication, the multiple proliferation of harmful cyanobacteria can form algal blooms and cause serious ecological problems. In recent years, the large-scale and persistent cyanobacterial blooms occur frequently worldwide and have attracted widespread attention due to the harmful impacts. Among these harmful bloom-forming cyanobacteria, the ecological and toxicological impacts of planktonic cyanobacteria have been extensively studied.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!