AI Article Synopsis
- Leptin and adiponectin are two cytokines from fat tissue that have opposing roles in tumor growth, with leptin promoting it and adiponectin inhibiting it.
- The study focused on specific genetic variations (polymorphisms) of the LEP and ADIPOQ genes in Mexican patients with colorectal cancer, comparing 68 patients with 102 healthy blood donors.
- Results indicated that the LEP A19G polymorphism was significantly associated with colorectal cancer, especially in males, while the ADIPOQ variations did not show any significant differences between the groups.
Article Abstract
Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ+45 T/G and +276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and 102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established by PCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differences between CRC patients and control group (p= 0.01 for G/A genotype and p= 0.02 for the recessive model G/G +G/A); yet, in the analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shown any significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3233/CBM-2010-0154 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!