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Phyto-mediated synthesis can be used for the sustainable fabrication of metallic nanoparticles (NPs). Ethanolic leaf extract of Acacia jacquemontii was used to phyto-fabricate iron oxide nanoparticles (FeO NPs). Synthesized FeO NPs were examined by various analytical techniques for their detailed chemical elemental and morphological features.
View Article and Find Full Text PDFIron-sulfur cluster proteins present the weak spot in non-thermal plasma-treated Escherichia coli.
Redox Biol
February 2025
Applied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany. Electronic address:
Non-thermal atmospheric pressure plasmas have an antiseptic activity beneficial in different medical applications. In a genome-wide screening, hydrogen peroxide and superoxide were identified as key species contributing to the antibacterial effects of plasma while [FeS] cluster proteins emerged as potential cellular targets. We investigated the impact of plasma treatment on [FeS] cluster homeostasis in Escherichia coli treated for 1 min with the effluent of a microscale atmospheric pressure plasma jet (μAPPJ).
View Article and Find Full Text PDFEstrogen replacement restores period 2-mediated inhibition of ferroptosis and mitigates cardiac dysfunction in estrogen-deficient rats.
J Pharmacol Exp Ther
February 2025
Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina. Electronic address:
The ovarian hormone 17β-estradiol (E2) confers cardioprotection via upregulating cardiac circadian rhythm period 2 (Per2) and is associated cardioprotective microRNA (miRNAs). However, whether Per2-mediated downregulation of ferroptosis-induced oxidative stress and injury in noncardiac tissues extends to the heart remains unknown. Therefore, studying the interplay between E2 and cardiac ferroptosis will have important ramifications for female cardiovascular health.
View Article and Find Full Text PDFSoybean Flour Fortified with Powder to Increase Iron Bioavailability Improves Gut Health and Oxidative Balance In Vivo.
Nutrients
January 2025
Laboratory of Vitamin Analysis, Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil.
Background: Insects like have an excellent nutritional profile, including iron. However, the bioavailability of this iron and its effects on intestinal health and oxidative balance remain unclear. To enhance acceptance, insects can be used in powder form and combined with common flours.
View Article and Find Full Text PDFIncreased Transferrin Concentrations Are Not Associated With Thrombosis in People Living at High Altitude.
J Hematol
February 2025
Department of Medicine, University of Illinois at Chicago, IL, USA.
Background: Bolivian Andean Aymara highlanders, living at 4,000 m for 14,000 years, have evolved genetic adaptations to hypoxia. These include encoding prolyl hydroxylase 2 (PHD2), a regulator of transferrin transcription. Transferrin level increases in hypoxia and iron deficiency.
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