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Introduction: Limited research is available regarding recommendations about which drug allergy alerts (DAAs) in clinical decision support (CDS) systems should interrupt provider workflow. The objective was to evaluate the frequency of penicillin and cephalosporin DAA overrides at two institutions. A secondary objective was to redesign DAAs using a new tiered alerting system based on patient factors.
View Article and Find Full Text PDFProteins have proven to be useful agents in a variety of fields, from serving as potent therapeutics to enabling complex catalysis for chemical manufacture. However, they remain difficult to design and are instead typically selected for using extensive screens or directed evolution. Recent developments in protein large language models have enabled fast generation of diverse protein sequences in unexplored regions of protein space predicted to fold into varied structures, bind relevant targets, and catalyze novel reactions.
View Article and Find Full Text PDFComparative accuracy assessment of analog and virtual wax-up in prosthetic-driven planning and guided implant surgery: A retrospective cohort study.
J Prosthodont Res
January 2025
Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Purpose: This retrospective cohort study evaluated the accuracy of analog versus virtual wax-ups in prosthetic-driven planning and guided surgery.
Methods: There were 73 patients with a single missing posterior tooth who underwent either an analog or virtual wax-up design following a prosthetic-driven concept. Intraoral scans of the final restoration were performed 1 year after completion of the restoration.
Redesigning error control in cross-linking mass spectrometry enables more robust and sensitive protein-protein interaction studies.
Mol Syst Biol
January 2025
Research group "Structural Interactomics", Leibniz Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany.
Cross-linking mass spectrometry (XL-MS) allows characterizing protein-protein interactions (PPIs) in native biological systems by capturing cross-links between different proteins (inter-links). However, inter-link identification remains challenging, requiring dedicated data filtering schemes and thorough error control. Here, we benchmark existing data filtering schemes combined with error rate estimation strategies utilizing concatenated target-decoy protein sequence databases.
View Article and Find Full Text PDFBackground: Specialty pharmacy practice requires unique patient-centric care, emphasizing high-cost medications, complex treatment regimens, and medications requiring special handling.
Objective: We conducted this study to assess the effect of specialty pharmacy practice on patient and healthcare provider (HCP) satisfaction and pharmacy practice-related outcomes.
Methods: This prospective, concurrent, and historically controlled cohort study was performed in an ambulatory care setting for over 6 months and included 6 specialties: neurology, pediatrics, dermatology, gastroenterology, pediatric liver transplantation, and medical genetics.
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