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Good Practices for Health Technology Assessment Guideline Development: A Report of the Health Technology Assessment International, HTAsiaLink, and ISPOR Special Task Force.
Value Health
October 2024
Health Intervention and Technology Assessment Program (HITAP), Ministry of Public Health, Nonthaburi, Thailand; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Objectives: Health technology assessment (HTA) guidelines are intended to support successful implementation of HTA by enhancing consistency and transparency in concepts, methods, process, and use, thereby enhancing the legitimacy of the decision-making process. This report lays out good practices and practical recommendations for developing or updating HTA guidelines to ensure successful implementation.
Methods: The task force was established in 2022 and comprised experts and academics from various geographical regions, each with substantial experience in developing HTA guidelines for national health policymaking.
The Daunomycin: Biosynthesis, Actions, and the Search for New Solutions to Enhance Production.
Microorganisms
December 2024
VUAB Pharma A.S, Nemanicka 2722, 370 01 České Budějovice, Czech Republic.
Daunorubicin (DNR) is an anthracycline antibiotic originating from soil-dwelling actinobacteria extensively used to treat malignant tumors. Over the decades, extensive attempts were made to enhance the production of anthracyclines by introducing genetic modifications and mutations in combination with media optimization, but the target production levels remain comparatively low. Developing an appropriate culture medium to maximize the yield of DNR and preventing autotoxicity for the producing organism remains a challenge.
View Article and Find Full Text PDFA Study of the Structure of an Anion Exchange Resin with a Quaternary Ammonium Functional Group by Using Infrared Spectroscopy and DFT Calculations.
Materials (Basel)
December 2024
Faculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2 Str., 30-387 Kraków, Poland.
The large numbers of ion exchange resins used in various industries (food, pharmaceutitics, mining, hydrometallurgy), and especially in water treatment, are based on cross-linked polystyrene and divinylbenzene copolymers with functional groups capable of ion exchange. Their advantage, which makes them environmentally friendly, is the possibility of their regeneration and reuse. Taking into account the wide application of these materials, styrene-divinylbenzene resin with a quaternary ammonium functional group, AmberliteIRA402, was characterized using a well-known and widely used method, FT-IR spectroscopy.
View Article and Find Full Text PDFScreening and Validation of Stable Reference Genes for qRT-PCR Analysis in (Coleoptera: Meloidae).
Insects
November 2024
Key Laboratory of Agricultural Genetically Modified Organisms Traceability, Oil Crops Research Institute of Chinese Academy of Agricultural Science/Supervision and Test Center (Wuhan) for Plant Ecological Environment Safety, Ministry of Agriculture and Rural Affairs, Wuhan 430062, China.
is a hypermetamorphic insect that mainly forage soybeans during the adult stage. However, the lack of appropriate references hinders our studying of the gene function in . In this study, referring to five computational tools (Ct value, geNorm, NormFinder, BestKeeper and RefFinder), the stability of 10 housekeeping genes (, , , , , , , , and ) was assessed by qRT-PCR under three different conditions (adult ages, tissues/organs and temperatures).
View Article and Find Full Text PDFThe Relationship of Creativity and Motor Creativity with Physical Activity and Motor Fitness in a Gender Perspective Among 8-9-Year-Old Children.
Children (Basel)
December 2024
Department of Didactics of Physical Activity, Poznan University of Physical Education, 61-871 Poznan, Poland.
Background: In this study, we aimed to determine the presence of any potential gender differences and relationships in terms of creativity, physical activity (PA), motor fitness, and motor creativity in children aged 8-9 years.
Methods: The study included 195 primary school children (92 girls and 103 boys) aged 8-9 years old from grade 2. To determine creativity, the Test for Creative Thinking-Drawing Production was used, while motor creativity was assessed using Torrance's 'Thinking Creatively in Action and Movement' test.
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