Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067635 | PMC |
| http://dx.doi.org/10.1128/JB.01210-10 | DOI Listing |
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