This paper presents a study that investigates the destructive energy output resulting from hydrodynamic bubbly cavitation in microchannels and its potential use in biomedical applications. The research performed in this study includes results from bubbly cavitation experiments and findings showing the destructive effects of bubbly cavitating flow on selected solid specimens and live cells. The bubbles generated by hydrodynamic cavitation are highly destructive at the surfaces of the target medium on which they are carefully focused. The resulting destructive energy output could be effectively used for biomedical treatments, such as destroying kidney stones (renal calculi) or killing cancer cells. Motivated by this potential, the cavitation damage to cancerous cells and material removal from chalk pieces (which possess similar material properties as some kidney stones) was investigated. Our results showed that cavitation could induce damage both on chalk pieces and leukemia/lymphoma cells. We discovered that hydrodynamic cavitation exposure had early and delayed effects on cancer cell survival. Hence, the potential of hydrodynamic bubbly cavitation generated at the microscale for biomedical treatments was revealed using the microchannel configuration as a microorifice (with an inner diameter of 147 μm and a length of 1.52 cm), which acts as the source of bubbly cavitating flows.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/TBME.2011.2107322 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structural acoustic design of a sonicator to enhance energy transfer efficiency.
Ultrason Sonochem
February 2024
Engineering Acoustics, Department of Civil, Environmental and Natural Resources, Luleå University of Technology, Luleå, Sweden. Electronic address:
The study focuses on developing a comprehensive design approach for a flow-through ultrasonic reactor (sonicator) to tackle challenges like low energy transfer efficiency and unstable system performance. The simulation accounts for structural vibrations, structural-fluid interactions, and pressure distributions within the cavitation zone under single-frequency excitation. Different geometrical designs of cylindrical sonicators are analyzed, with input parameters tailored to acquire higher acoustic cavitation intensity.
View Article and Find Full Text PDFExtensive investigation of geometric effects in sonoreactors: Analysis by luminol mapping and comparison with numerical predictions.
Ultrason Sonochem
October 2023
Laboratoire de Genie Chimique, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France.
This investigation focuses on the influence of geometric factors on cavitational activity within a 20kHz sonoreactor containing water. Three vessels with different shapes were used, and the transducer immersion depth and liquid height were varied, resulting in a total of 126 experiments conducted under constant driving current. For each one, the dissipated power was quantified using calorimetry, while luminol mapping was employed to identify the shape and location of cavitation zones.
View Article and Find Full Text PDFSimultaneous hydrodynamic cavitation and nanosecond pulse discharge plasma enhanced by oxygen injection.
Ultrason Sonochem
October 2023
Department of Electrical Engineering, Tsinghua University, Beijing 100084, China. Electronic address:
A novel Hydrodynamic Cavitation-Assisted Oxygen Plasma (HCAOP) process, which employs a venturi tube and oxygen injection, has been developed for enhancing the production and utilization of hydroxyl radicals (·OH) in the degradation of organic pollutants. This study has systematically investigated the fluid characteristics and discharge properties of the gas-liquid two-phase body in the venturi tube. The hydraulic cavitation two-phase body discharge is initiated by the bridging of the cavitation cloud between the electrodes.
View Article and Find Full Text PDFProbing the pressure dependence of sound speed and attenuation in bubbly media: Experimental observations, a theoretical model and numerical calculations.
Ultrason Sonochem
May 2023
Department of Physics, Toronto Metropolitan University, Toronto, Canada; Institute for Biomedical Engineering, Science and Technology (IBEST) a partnership between Ryerson University and St. Mike's Hospital, Toronto, Ontario, Canada. Electronic address:
The problem of attenuation and sound speed of bubbly media has remained partially unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation and sound speed of a bubbly medium are not available. Our theoretical understanding of the problem is limited to linear or semi-linear theoretical models, which are not accurate in the regime of large amplitude bubble oscillations.
View Article and Find Full Text PDFA computational framework for the multiphysics simulation of microbubble-mediated sonothrombolysis using a forward-viewing intravascular transducer.
Ultrasonics
May 2023
School of Engineering and Information Technology, Faculty of Science and Technology, Federation University, VIC 3350, Australia.
Sonothrombolysis is a technique that utilises ultrasound waves to excite microbubbles surrounding a clot. Clot lysis is achieved through mechanical damage induced by acoustic cavitation and through local clot displacement induced by acoustic radiation force (ARF). Despite the potential of microbubble-mediated sonothrombolysis, the selection of the optimal ultrasound and microbubble parameters remains a challenge.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!