Background: The optimal plate location and fixation method for midshaft fractures of the clavicle remains undetermined. The objective of this study was to develop a realistic biomechanical model with which to compare superior with inferior-medial plate placement, and the failure resistance of locked and against non-locked constructs.
Methods: We estimated implant loads for operated patients in early rehabilitation utilising 3-D mathematical model of the shoulder. During simulation of upper limb motion associated with eating, the fracture opened in an inferior and frontal direction. The peak X, Y, and Z loads from the simulation were reproduced using a materials testing machine. A one centimetre transverse osteectomy was created at the midshaft of forty composite clavicles. Each specimen was then fixed with either (1) non-locked superior plating (n=10), (2) locked superior plating (n=10), (3) non-locked inferior-medial plating (n=10), or (4) locked inferior-medial plating (n=10). Specimens were loaded at 20 N/s in four-point bending for 50 cycles to the peak X, Y, Z moment obtained from the computational model (-3.50, 2.46, and -1.00 N m), then loaded to failure at 20 N/s.
Findings: Inferior-medial unlocked plates were significantly stiffer than superior locked plates (P=0.046).
Interpretation: Operative fixation of midshaft clavicle fractures is controversial, though becoming more widely accepted. Few biomechanical data are available to assist surgical decision-making. Inferior plates may be better equipped to resist the in vivo loads experienced by the clavicle during early rehabilitation after internal fixation, particularly during the shoulder flexion motions associated with eating.
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http://dx.doi.org/10.1016/j.clinbiomech.2010.12.007 | DOI Listing |
Int J Parasitol Parasites Wildl
April 2025
Institute of Veterinary Medicine, Georg-August-University of Goettingen, Burckhardtweg 2, 37077, Goettingen, Germany.
Infections with soil-transmitted helminths pose a significant threat to wildlife in enclosures, where transmission of these parasitic larvae is easier due to the limited space. Nematophagous fungi offer a promising solution as they can naturally control these nematodes. In this study, three nematophagous fungi (, , ) purchased from the non-profit global biological resource center ATCC were tested for their suitability as biological control agents.
View Article and Find Full Text PDFPLoS One
December 2024
Mesa Photonics, Santa Fe, NM, United States of America.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants are a continuous threat to human life. An urgent need remains for simple and fast tests that reliably detect active infections with SARS-CoV-2 and its variants in the early stage of infection. Here we introduce a simple and rapid activity-based diagnostic (ABDx) test that identifies SARS-CoV-2 infections by measuring the activity of a viral enzyme, Papain-Like protease (PLpro).
View Article and Find Full Text PDFArch Orthop Trauma Surg
December 2024
Department of Orthopedic Surgery, University of Miami Miller School of Medicine, NW 14th Street, Miami, FL, 33136, USA.
Objective: What is the effect of surgical or conservative treatment on the in-hospital outcomes of patients with combined fractures of the clavicle and ribs?
Design: Retrospective cohort study.
Setting: Two level-1 trauma centers and academic teaching hospitals in Boston, Massachusetts.
Patients: All adult patients with a clavicle fracture and ≥3 rib fractures admitted from 2016 to 2021.
Osteoarthritis Cartilage
December 2024
National Creative Research Initiatives Center for Osteoarthritis Pathogenesis and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea. Electronic address:
Biomedicines
November 2024
Department of Ophthalmology, Korea University College of Medicine, Ansan Hospital, Ansan 15355, Republic of Korea.
The aim of this study was to develop 3D-bioprinted scaffolds embedded with human adipose-derived stem cells (hADSCs) to reconstruct the tarsal plate in a rat model. Scaffolds were printed using a 3D bioprinter with a bioink composed of atelocollagen and alginate. hADSCs (5 × 10 cells/mL) were embedded within the bioink.
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