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Molecular Mechanisms of Alzheimer's Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy.
Cells
January 2025
Department of Biochemistry, Hallym University College of Medicine, Chuncheon 24252, Kangwon-do, Republic of Korea.
Amyloid-β peptide (Aβ) is a critical cause of Alzheimer's disease (AD). It is generated from amyloid precursor protein (APP) through cleavages by β-secretase and γ-secretase. γ-Secretase, which includes presenilin, is regulated by several stimuli.
View Article and Find Full Text PDFA Self-Reinforced "Microglia Energy Modulator" for Synergistic Amyloid-β Clearance in Alzheimer's Disease Model.
Angew Chem Int Ed Engl
December 2024
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang, Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.
Microglial phagocytosis is a highly energy-consuming process that plays critical roles in clearing neurotoxic amyloid-β (Aβ) in Alzheimer's disease (AD). However, microglial metabolism is defective overall in AD, thereby undermining microglial phagocytic functions. Herein, we repurpose the existing antineoplastic drug lonidamine (LND) conjugated with hollow mesoporous Prussian blue (HMPB) as a "microglial energy modulator" (termed LND@HMPB-T7) for safe and synergistic Aβ clearance.
View Article and Find Full Text PDFLong COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity.
Pediatr Res
November 2024
Department of Physiology, Semmelweis University, Budapest, Hungary.
Background: Many children suffer from lingering symptoms after COVID-19, known as long COVID syndrome (LCS), otherwise called Post COVID-19 Condition (PCC). Despite extensive research, the prevalence of symptoms, its impact on quality of life, and underlying mechanisms still need to be fully understood. As neutrophilic granulocytes play an essential role in COVID-19, and their prolonged disruption was found to cause immunological diseases, we hypothesized their ongoing disturbed functionality in LCS.
View Article and Find Full Text PDFInsulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia.
J Inflamm Res
November 2024
Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Introduction: Insulin, the key hormone for glucose regulation, has garnered attention for its role as an immune modulator. Impaired insulin signaling in the central nervous system is linked to neuroinflammation and neurodegenerative diseases. Microglia, the resident macrophage-like immune cells in the brain, are key regulators of neuroinflammation.
View Article and Find Full Text PDFNutritional Innovation Using Green Seaweed (Ulva sp.) and Garlic Powder Extracts for White-Leg Shrimp (Litopenaeus vannamei) Challenged by Vibrio harveyi.
Vet Med Sci
November 2024
Department of Parasitology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Article Synopsis
- The study investigated the antimicrobial properties of ethanolic extracts from Ulva sp. and garlic powder against the bacteria Vibrio harveyi, and their effects on white-leg shrimp growth and immune response.
- The research involved feeding shrimp a diet enriched with varying amounts of these extracts and observing changes in health and performance over 60 days.
- Results showed that while the extracts improved immune responses and antibacterial activity, they did not significantly impact weight gain or survival rates compared to a control diet.
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