E.I.Smirnov's views of the role and place of organizational aspects of the greatest Russian surgeon N.I.Pirogov in development of modern medical supply system are covered on the basis of vast historiographical data. From the perspectives of historism and objectivism a degree of realization Pirogov's ideas during creation of the consistent military-medicine doctrine and organization of medical-evacuational measures during the Great Patriotic War 1941-1945 is analyzed.
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Comput Biol Med
January 2025
National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India. Electronic address:
The biotransformation of drugs by enzymes from the human microbiome can produce active or inactive products, impacting the bioactivity and function of these drugs inside the human host. However, understanding the biotransformation reactions of drug molecules catalyzed by bacterial enzymes in human microbiota is still limited. Hence, to characterize drug utilization capabilities across all the microbial phyla inside the human gut, we have used a knowledge-based approach to develop HgutMgene-Miner software which predicts xenobiotic metabolizing enzymes (XMEs) through genome mining.
View Article and Find Full Text PDFEnviron Manage
January 2025
School of Environment and Science, Griffith University, 170 Kessels Road, Nathan, 4111, Australia.
Street and park trees often endure harsher conditions, including increased temperatures and drier soil and air, than those found in urban or natural forests. These conditions can lead to shorter lifespans and a greater vulnerability to dieback. This literature review aimed to identify confirmed causes of street and park tree dieback in urban areas from around the world.
View Article and Find Full Text PDFPlanta
January 2025
School of Life Sciences and Technology, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung, 40132, Indonesia.
The exogenous application of RNAi technology offers new promises for crops improvement. Cell-based or synthetically produced strands are economical, non-transgenic and could induce the same responses. The substantial population growth demands novel strategies to produce crops without further damaging the environment.
View Article and Find Full Text PDFViruses
December 2024
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, China.
Toscana virus (TOSV), a member of the genus transmitted by sandflies, is acknowledged for its capacity to cause neurological infections and is widely distributed across Mediterranean countries. The potential geographic distribution and risk to the human population remained obscure due to its neglected nature. We searched PubMed and Web of Science for articles published between 1 January 1971 and 30 June 2023 to extract data on TOSV detection in vectors, vertebrates and humans, clinical information of human patients, as well as the occurrence of two identified sandfly vectors for TOSV.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Horticulture and Life Science, Yeungnam University, Gyeongsan 38541, Republic of Korea.
The development of resistance to traditional antifungal therapies has necessitated the exploration of alternative treatment strategies to effectively manage fungal infections, particularly those induced by (). This research investigates the possibility of integrating silver nanoparticles (AgNPs) with Terbinafine to improve antifungal effectiveness. Terbinafine, while potent, faces challenges with specific fungal strains, highlighting the need for strategies to enhance its treatment efficacy.
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