Experimental data on the influence of omnipak-350 introduction in a dose of 20 g/kg on the glutathione exchange processes and lipide peroxidation in kidneys, liver and erythrocytes of white outbred rats are presented. The possibility of using cytoflavin for correcting x-ray contrast agent-induced disorders in the natural cytoprotective system is shown. Probable mechanisms of the cytoprotective effect of the proposed pharmacological treatment are discussed.
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Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Saint Petersburg State University, St. Petersburg, Russia.
Objective: To evaluate the autonomic dysfunction of cardiovascular system (CVS) in patients with post-COVID syndrome with the help of active orthotest and heart rate variability methods.
Material And Methods: 70 patients with PCOS were examined, who were divided into 2 groups. Group 1 patients received standard therapy and Cytoflavin for 35 days, Group 2 patients received only standard therapy.
Zh Nevrol Psikhiatr Im S S Korsakova
September 2024
Ivano-Matreninsk City Children's Clinical Hospital, Irkutsk, Russia.
In the presented clinical observation of complex therapy of severe combined trauma: severe brain contusion, subarachnoid hemorrhage, closed fracture of the occipital bone, closed compression fracture of Th-Th vertebral bodies, contusion of the lungs and kidneys, blunt abdominal trauma and closed fracture of both bones of the right leg in lower third with displacement) in a teenager after an accident, the need for dynamic introscopic examination of the patient is shown for timely detection of abnormalities in the state of brain structures and correction of treatment up to surgical intervention. The effectiveness of the inclusion of Cytoflavin in complex treatment regimens was noted in the form of positive dynamics of the clinical and introscopic picture. The results obtained may serve as a basis for further research.
View Article and Find Full Text PDFThe adverse outcomes in patients with COVID-19 in the initial phase of the disease are often due to the development of cytokine storm, endothelial dysfunction, shifts in the hemostasis system, microangiopathy, angiocentric inflammation, and pathological angiogenesis, which require targeted therapy. Unfortunately, to date, there is still no drug with proven high efficacy. This review is to analyse the literature data on the pathogenesis of vascular homeostasis lesions and possible ways to correct the existing shifts in patients with COVID-19.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
April 2023
Novosibirsk State Medical University, Novosibirsk, Russia.
Objective: To study the effect of the combined drug Cytoflavin on the mechanisms of nonspecific inflammation in the treatment of diabetic polyneuropathy (DPN) with an assessment of the dynamics of the TNF-α index.
Material And Methods: An open comparative prospective observation of patients with a history of DPN for more than 5 years and a high level of TNF-α was carried out. All patients underwent basic oral combined hypoglycemic therapy, the main group used the combined drug Cytoflavin 10 ml (per 200 ml 0.
Zh Nevrol Psikhiatr Im S S Korsakova
September 2022
Omsk State Medical University, Omsk, Russia.
Objective: To establish the prognostic significance of a biomarker of excitotoxic brain damage (antibodies to the NR2 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor) as a predictor of damage to the central nervous system (CNS) in preterm infants.
Material And Methods: 24 newborns with a gestational age of 24-33 weeks were examined with the determination of the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life.
Results: In the course of the study, it was found that the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life, in combination with the level of cord blood lactate and the resistance of cerebral vessels on the 1st day of life, can be predictors of CNS damage in a premature baby at the age of 1 month of corrected age.
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