AI Article Synopsis
- The study focuses on synthesizing heterodimers using a specific polymer and a prodrug, which shows potential as photoresponsive drug delivery systems.
- Drug release tests and NMR spectroscopy are highlighted as key methods for demonstrating effective drug immobilization and structural analysis of the synthetic heterodimers.
- The research identifies different types of dimers formed from the copolymer and provides insights into their formation, indicating the significance of specific polymer structures in developing new drug delivery technologies.
Article Abstract
Heterodimers based on the polymer-bound chromophore 4-methylcoumarin and the prodrug 1-heptanoyl-5-fluorouracil, synthesized by photochemical [2 + 2]-cycloaddition are promising photoresponsive drug depots. Drug release experiments are one possibility to deliver proof of a successful reversible drug immobilization, whereas NMR spectroscopy is a potent tool for further structural characterization of these polymer-bound heterodimers. In case of the random copolymer poly(methyl methacrylate-co-7-(2'-methacryloyloxyethoxy)-4-methylcoumarin) three dimers have been identified of which the syn head-to-tail was the predominant one. In contrast, only the syn head-to-head dimer was formed in reasonable yield when the 4-methylcoumarin monofunctionalized pMMA was used as the base polymer. 1D and 2D NMR spectroscopic techniques combined with some theoretical calculations helped in successfully closing one major gap concerning polymer bound 4-methylcoumarin/1-heptanoyl-5-fluorouracil heterodimers that are of potential use in photoresponsive drug delivery devices.
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| http://dx.doi.org/10.1002/mrc.2711 | DOI Listing |
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