AI Article Synopsis
- The study examined how 3,4,5,6-tetrahydroxyxanthone affects connexin43 (Cx43) expression in endothelial cells exposed to lysophosphatidylcholine (LPC).
- Treatment with 3,4,5,6-tetrahydroxyxanthone reduced harmful reactive oxygen species (ROS) and asymmetric dimethylarginine (ADMA) levels, while also improving cell viability and increasing Cx43 expression.
- The findings suggest that 3,4,5,6-tetrahydroxyxanthone may help protect against atherosclerosis by lowering ADMA and enhancing Cx43 levels in the context of LPC-induced damage.
Article Abstract
To observe the direct effects of 3,4,5,6-tetrahydroxyxanthone on connexin43 (Cx43) expression in cultured endothelial cells, cells were treated with lysophosphatidylcholine (LPC, 10 mg/l) for 24 h in the presence or absence of different concentrations of 3,4,5,6-tetrahydroxyxanthone (1, 3, or 10 μmol l(- 1)). The reactive oxygen species (ROS) production, cell viability, asymmetric dimethylarginine (ADMA) levels, and Cx43 expression were detected. 3,4,5,6-Tetrahydroxyxanthone significantly inhibited the increase in ROS production and ADMA level, increased cell viability and up-regulated Cx43 mRNA and protein expression induced by LPC. 3,4,5,6-Tetrahydroxyxanthone has protective effect in LPC-induced atherosclerotic lesions, which is at least partly related to the reduction of ADMA level and downregulation of Cx43 expression.
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| http://dx.doi.org/10.1080/10286020.2010.539181 | DOI Listing |
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