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Introduction: A recent scoping review identified histological chorioamnionitis (HCA), small for gestational age (SGA), and bubbly/cystic appearance on chest X-ray (bubbly/cystic CXR) as risk factors for severe bronchopulmonary dysplasia (BPD). To further validate these results, a large-scale database was analyzed.
Methods: This retrospective multicenter cohort study included infants born at <28 weeks' gestational age between 2003 and 2016.
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder, but its genetic architecture remains incompletely characterized. Rare coding variants, which can profoundly impact gene function, represent an underexplored dimension of ADHD risk. In this study, we analyzed large-scale DNA sequencing datasets from ancestrally diverse cohorts and observed significant enrichment of rare protein-truncating and deleterious missense variants in highly evolutionarily constrained genes.
View Article and Find Full Text PDFTachycardia-Induced Cardiomyopathy Following Prolonged Ritodrine Infusion During Pregnancy: A Case Report.
Cureus
December 2024
Department of Obstetrics and Gynecology, Sakakibara Heart Institute, Fuchu, JPN.
Preterm birth remains a leading cause of neurodevelopmental disability in offspring, prompting various preventive measures. However, controversies persist surrounding these approaches, particularly regarding beta-mimetic drugs. In Japan, it remains a concerning reality that ritodrine infusion continues to be used for long-term tocolysis in preterm labor, despite the warning issued by the US Food and Drug Administration.
View Article and Find Full Text PDFNeurodivergence and Threat: A Case Study on the Risk of Violent Fixations in Autism Spectrum Disorder.
Cureus
December 2024
Child and Adolescent Inpatient Unit, Tower Behavioral Health, Reading, USA.
Mass shootings have increasingly captured public attention in recent decades, prompting closer examination of the mental health of those responsible. This scrutiny often focuses on individuals with neurodevelopmental disorders, such as autism spectrum disorder (ASD). While epidemiological evidence is mixed on whether these individuals are more likely to commit acts of violence than the general public, certain behavioral characteristics may make them more vulnerable to extremist ideations.
View Article and Find Full Text PDFReliability of the Alberta Infant Motor Scale (AIMS) When Used via Telehealth for Neurodevelopmentally High-Risk Infants.
Phys Occup Ther Pediatr
January 2025
Physiotherapy Program, School of Health Sciences, Western Sydney University, NSW, Australia.
Aims: To assess the reliability of the Alberta Infant Motor Scale (AIMS) when conducted recorded telehealth sessions by novice and expert raters.
Methods: Ten assessors (six novice, four expert) independently rated recorded telehealth assessments of 23 neurodevelopmentally high-risk infants twice. Inter- and intra-rater reliability of subscale scores, total score and percentile rankings were determined.
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