AI Article Synopsis
- The study aimed to investigate the anti-inflammatory properties of a crude aqueous extract from Bixa orellana leaves and how nitric oxide (NO) is involved in this process.
- The extract was prepared by soaking the powdered leaves in water, and it showed significant effectiveness in reducing inflammation in various tests conducted on rats.
- Findings suggest that B. orellana leaves' anti-inflammatory effects may be linked to inhibiting bradykinin and reducing NO production, supporting their traditional use for treating inflammation.
Article Abstract
Objective: The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism.
Materials And Methods: The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (yield 8.5% w/w). The dosage was recorded as the mass of extract per kg b.w. of rats in all inflammatory assays (bradykinin-induced paw edema, peritoneal vascular permeability and NO assay).
Results: Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. In addition, AEBO was also found to significantly suppress the production of NO at doses of 50 and 150 mg/kg.
Conclusion: This study provides scientific data to support the traditional use of B. orellana leaves in treating inflammation. Results from this study suggest that AEBO exerts anti-inflammatory effects. Part of this anti-inflammatory effect may be associated with its antibradykinin activity and may be related to a reduction of the NO production.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000319907 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Coffee farmers willingness to accept payments for ecosystem services: Evidence from a choice experiment in Honduras.
J Environ Manage
March 2025
Centro Universitario Regional de Occidente, Universidad Nacional Autónoma de Honduras, Honduras.
Coffee production in Central America provides a valuable yet volatile source of income for hundreds of thousands of small-scale farmers and employment for millions of workers. Expansion of coffee production into previously forested areas has caused the loss of a wide range of valuable ecosystem goods and services while contributing to global climate change and socioeconomic instability. Growth in carbon markets in agricultural settings and production of specialty coffees to meet consumer demands for products that support environmental and community outcomes suggests promise for favorable change.
View Article and Find Full Text PDF"Don't leave us behind": a qualitative study exploring the feasibility of a palliative care training program for non-health caregivers in Honduras.
Palliat Care Soc Pract
February 2025
Department of Nursing, Universidad Nacional Autónoma de Honduras-UNAH Campus Atlántida, La Ceiba, Honduras.
Background: Palliative care (PC) can alleviate suffering and improve quality of life. Yet, disparities persist, particularly in Honduras. Training efforts in PC for non-health caregivers have proven to reduce burnout and stress while enhancing the quality of life for both caregivers and patients.
View Article and Find Full Text PDFAssessing and comparing compassionate communities benefits across cities in diverse cultural contexts: a step toward the identification of the most important ones.
Palliat Care Soc Pract
January 2025
University Center for Palliative Care, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Background: As Compassionate Communities (CCs) are developing worldwide, there is a growing need to systematically assess if they are having the expected effects on the community. Although having a single strategy would be ideal in terms of standardization and comparison, due to the inherent heterogeneity of CCs, it is not known how feasible this would be.
Objectives: To assess the feasibility of creating a general strategy, based on the results of a series of focus groups conducted across three diverse CCs, to guide the evaluation of already existing programs and the development of new ones.
Growth-tolerance tradeoffs shape the survival outcomes and ecophysiological strategies of Atlantic Forest species in the rehabilitation of mining-impacted sites.
Sci Total Environ
February 2025
Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais 31270-901, Brazil. Electronic address:
The initial performance of seedlings of tree species from different functional groups, regarding the growth-defense tradeoff, might determine its long-term success during the rehabilitation of mining areas. We monitored the field performance of six native tree species of the Atlantic Forest in the Fundão dam tailing that has been under rehabilitation for 35 months. Additionally, we explored the morphophysiological traits driving the superior performance of three species.
View Article and Find Full Text PDFIn Vitro Evaluation of the Antifungal Properties of L. Essential Oil from the Ecuadorian Amazon Against (ATCC 10231).
Life (Basel)
December 2024
Facultad de Ciencias de la Tierra, Universidad Estatal Amazónica (UEA), Vía Tena km 2½, Puyo 160150, Pastaza, Ecuador.
Essential oils are investigated due to their biological activity, and the Amazon rainforest, with its rich biodiversity, is a promising source of therapeutic compounds. The aim of this study was to evaluate the essential oil from the leaves of as an antifungal agent, thus contributing to the search for alternatives that can address the growing resistance to conventional antifungals. leaves were collected in the Ecuadorian Amazon and their essential oil was obtained by steam distillation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!