AI Article Synopsis
- The study examines the role of T-cadherin (T-cad) expression in bladder transitional cell carcinoma (TCC) by analyzing tissue samples from 113 cancer patients and 37 normal controls.
- Results showed lower T-cad expression in TCC samples, which was linked to more advanced disease stages, higher tumor grades, larger tumor sizes, and increased likelihood of relapse.
- While low T-cad expression correlated with poorer overall survival, it was not identified as a standalone prognostic indicator.
Article Abstract
Objective: To investigate the clinical significance of T-cadherin (T-cad) tissue expression in patients with bladder transitional cell carcinoma (TCC).
Materials And Methods: T-cad expression in 113 bladder TCC specimens and 37 normal controls were examined by immunohistochemical staining, and the results were correlated with clinicopathologic parameters. The χ(2) test, Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazard model were used for statistical analysis.
Results: T-cad expression in bladder TCC samples was lower than in the controls. Decreased T-cad expression was correlated with advanced stage (p = 0.0027), high grade (p = 0.0078), large tumor size (p = 0.0262), and tumor relapse (p = 0.0293), but no association was found among T-cad expression and age (p = 0.1265), gender (p = 0.4236), tumor number (p = 0.0595) or tumor shape (p = 0.1779). Moreover, decreased T-cad expression was significantly associated with poor overall survival (p = 0.0168), even though it is not an independent prognostic marker (p = 0.2005).
Conclusions: Decreased T-cad expression in tumor tissues is closely associated with malignancy in bladder TCC.
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| http://dx.doi.org/10.1159/000322962 | DOI Listing |
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